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Gene Review

EEF1B2  -  eukaryotic translation elongation factor 1...

Homo sapiens

Synonyms: EEF1B, EEF1B1, EF-1-beta, EF1B, Elongation factor 1-beta
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Disease relevance of EEF1B2


High impact information on EEF1B2


Biological context of EEF1B2


Anatomical context of EEF1B2


Associations of EEF1B2 with chemical compounds

  • In human fibroblasts, the guanine nucleotide exchange part of EF-1, EF-1 beta gamma delta, was found to co-localize with the endoplasmic reticulum (ER), displaying a distinct fine-structure in its staining pattern [6].
  • The derived amino acid sequence, corresponding to a protein of 225 amino acids, shows a high degree of homology to elongation factor 1 beta (EF-1 beta) of Artemia salina (57%) and known peptide sequences of Xenopus laevis EF-1 beta (86%) [7].
  • Three forms of elongation factor 1 (EF1A, EF1B and EF1C) were isolated from wheat germ; the preparation obtained by successive chromatography on DEAE-Sephadex A-50, hydroxylapatite and Sephadex G-200 showed about 90% purity [10].
  • Results indicate that higher level of EF-1beta' expression is necessary for auxin- and zinc-induced root formation in rice [11].
  • Echinococcus allergens include (1) AgB 12-kDa subunit, a protease inhibitor and a potent Th2 inducer; (2) Ag5, a serine protease; (3) EA 21, a specific cyclophilin, with a homology with other types of cyclophilins; (4) Eg EF-1 beta/delta an elongation factor, with a homology with Strongyloides stercoralis EF that shares the same IgE epitope [12].

Physical interactions of EEF1B2


Other interactions of EEF1B2

  • Humans have a single intron-containing locus, EEF1B2, which maps to 2q33, and an intronless paralogue expressed only in brain and muscle (EEF1B3) [14].
  • In this report, we demonstrate that three components of EF-1H (EF-1 beta, EF-1 delta, EF-1 gamma) bind to DNA modified with chromium (Cr), a potent DNA-damaging agent and an established human carcinogen [15].
  • A polyvalent antiserum against EF-1 beta and two monoclonal antibodies against EF-1 gamma were used to identify the protein fragments in this core [16].
  • High temperature (35/30 degrees C) decreased the expression of Wx proteins, allergen-like proteins, and elongation factor 1beta, but increased the expression of small heat shock proteins (sHSP), glyceraldehyde-3-phosphate dehydrogenase, and prolamin. sHSP was positively correlated with the appearance of chalky kernels [17].

Analytical, diagnostic and therapeutic context of EEF1B2


  1. The solution structure of the guanine nucleotide exchange domain of human elongation factor 1beta reveals a striking resemblance to that of EF-Ts from Escherichia coli. Pérez, J.M., Siegal, G., Kriek, J., Hård, K., Dijk, J., Canters, G.W., Möller, W. Structure (1999) [Pubmed]
  2. Comparative protein profiling identifies elongation factor-1beta and tryparedoxin peroxidase as factors associated with metastasis in Leishmania guyanensis. Walker, J., Acestor, N., Gongora, R., Quadroni, M., Segura, I., Fasel, N., Saravia, N.G. Mol. Biochem. Parasitol. (2006) [Pubmed]
  3. Elongation factor 1 beta/delta of Echinococcus granulosus and allergic manifestations in human cystic echinococcosis. Ortona, E., Margutti, P., Vaccari, S., Riganò, R., Profumo, E., Buttari, B., Chersi, A., Teggi, A., Siracusano, A. Clin. Exp. Immunol. (2001) [Pubmed]
  4. Purification and characterization of three elongation factors, EF-1 alpha, EF-1 beta gamma, and EF-2, from wheat germ. Lauer, S.J., Burks, E., Irvin, J.D., Ravel, J.M. J. Biol. Chem. (1984) [Pubmed]
  5. Plasmodium protein phosphatase 2C dephosphorylates translation elongation factor 1beta and inhibits its PKC-mediated nucleotide exchange activity in vitro. Mamoun, C.B., Goldberg, D.E. Mol. Microbiol. (2001) [Pubmed]
  6. Immunofluorescence studies of human fibroblasts demonstrate the presence of the complex of elongation factor-1 beta gamma delta in the endoplasmic reticulum. Sanders, J., Brandsma, M., Janssen, G.M., Dijk, J., Möller, W. J. Cell. Sci. (1996) [Pubmed]
  7. Human elongation factor 1 beta: cDNA and derived amino acid sequence. von der Kammer, H., Klaudiny, J., Zimmer, M., Scheit, K.H. Biochem. Biophys. Res. Commun. (1991) [Pubmed]
  8. Nucleotide sequence of human elongation factor-1 beta cDNA. Sanders, J., Maassen, J.A., Amons, R., Möller, W. Nucleic Acids Res. (1991) [Pubmed]
  9. Human elongation factor EF-1 beta: cloning and characterization of the EF1 beta 5a gene and assignment of EF-1 beta isoforms to chromosomes 2,5,15 and X. Pizzuti, A., Gennarelli, M., Novelli, G., Colosimo, A., Lo Cicero, S., Caskey, C.T., Dallapiccola, B. Biochem. Biophys. Res. Commun. (1993) [Pubmed]
  10. The elongation factor 1 from wheat germ: structural and functional properties. Pulikowska, J., Twardowski, T. Acta Biochim. Pol. (1982) [Pubmed]
  11. A proteomic approach to analyze auxin- and zinc-responsive protein in rice. Yang, G., Inoue, A., Takasaki, H., Kaku, H., Akao, S., Komatsu, S. J. Proteome Res. (2005) [Pubmed]
  12. Echinococcosis and allergy. Vuitton, D.A. Clinical reviews in allergy & immunology. (2004) [Pubmed]
  13. Identification of the sites in the eukaryotic elongation factor 1 alpha involved in the binding of elongation factor 1 beta and aminoacyl-tRNA. van Damme, H.T., Amons, R., Möller, W. Eur. J. Biochem. (1992) [Pubmed]
  14. Comparative genomic analysis of genes encoding translation elongation factor 1B(alpha) in human and mouse shows EEF1B1 to be a recent retrotransposition event. Chambers, D.M., Rouleau, G.A., Abbott, C.M. Genomics (2001) [Pubmed]
  15. DNA binding activity of the mammalian translation elongation complex: recognition of chromium- and transplatin-damaged DNA. Wang, J.F., Engelsberg, B.N., Johnson, S.W., Witmer, C., Merrick, W.C., Rozmiarek, H., Billings, P.C. Arch. Toxicol. (1997) [Pubmed]
  16. Mapping the functional domains of the eukaryotic elongation factor 1 beta gamma. van Damme, H., Amons, R., Janssen, G., Möller, W. Eur. J. Biochem. (1991) [Pubmed]
  17. Proteomic analysis of the expression of proteins related to rice quality during caryopsis development and the effect of high temperature on expression. Lin, S.K., Chang, M.C., Tsai, Y.G., Lur, H.S. Proteomics (2005) [Pubmed]
  18. Cloning and sequence analysis of the cDNA encoding the elongation factor-1 beta of Dictyostelium discoideum. Chae, S., Maeda, Y. Biochim. Biophys. Acta (1998) [Pubmed]
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