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Gene Review

Ef1beta  -  Elongation factor 1 beta

Drosophila melanogaster

Synonyms: 154264_at, BcDNA.LD24492, BcDNA:LD24492, CG6341, Dmel\CG6341, ...
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High impact information on Ef1beta

  • Immunoprecipitation assays of Drosophila nuclear extracts show that the exosome also associates with the elongation factor dSpt5 and RNA polymerase II [1].
  • This observation indicates a dynamic pattern of localization of dELL in cells, which is a predicted characteristic of a Pol II general elongation factor [2].
  • Decoding of UGA selenocysteine codons in eubacteria is mediated by the specialized elongation factor SelB, which conveys the charged tRNA(Sec) to the A site of the ribosome, through binding to the SECIS mRNA hairpin [3].
  • Productive elongation complexes are derived from early paused elongation complexes by the action of a factor which we call P-TEF (positive transcription elongation factor) [4].
  • We have identified a missense mutation (W049) in the gene encoding the transcriptional elongation factor Spt5 (reviewed in ) which, when homozygous in the maternal germ line, leads to defects in segmental patterning of the embryo [5].

Biological context of Ef1beta


Anatomical context of Ef1beta


Associations of Ef1beta with chemical compounds

  • We previously proposed the existence of an activity, P-TEF (positive transcription elongation factor) that functions in a DRB-sensitive manner to allow RNA polymerase II elongation complexes to efficiently synthesize long transcripts (Marshall, N. F. and Price, D. H. (1992) Mol. Cell. Biol. 12, 2078-2090) [10].

Other interactions of Ef1beta


  1. The RNA processing exosome is linked to elongating RNA polymerase II in Drosophila. Andrulis, E.D., Werner, J., Nazarian, A., Erdjument-Bromage, H., Tempst, P., Lis, J.T. Nature (2002) [Pubmed]
  2. Drosophila ELL is associated with actively elongating RNA polymerase II on transcriptionally active sites in vivo. Gerber, M., Ma, J., Dean, K., Eissenberg, J.C., Shilatifard, A. EMBO J. (2001) [Pubmed]
  3. Characterization of mSelB, a novel mammalian elongation factor for selenoprotein translation. Fagegaltier, D., Hubert, N., Yamada, K., Mizutani, T., Carbon, P., Krol, A. EMBO J. (2000) [Pubmed]
  4. Control of formation of two distinct classes of RNA polymerase II elongation complexes. Marshall, N.F., Price, D.H. Mol. Cell. Biol. (1992) [Pubmed]
  5. Locus-specific requirements for Spt5 in transcriptional activation and repression in Drosophila. Jennings, B.H., Shah, S., Yamaguchi, Y., Seki, M., Phillips, R.G., Handa, H., Ish-Horowicz, D. Curr. Biol. (2004) [Pubmed]
  6. The effects of enhanced expression of elongation factor EF-1 alpha on lifespan in Drosophila melanogaster. IV. A summary of three experiments. Stearns, S.C., Kaiser, M. Genetica (1993) [Pubmed]
  7. Ribosomal protein P0 from Aedes albopictus mosquito cells: cDNA cloning and analysis of expression. Jayachandran, G., Fallon, A.M. Genetica (2003) [Pubmed]
  8. Cdk9 is an essential kinase in Drosophila that is required for heat shock gene expression, histone methylation and elongation factor recruitment. Eissenberg, J.C., Shilatifard, A., Dorokhov, N., Michener, D.E. Mol. Genet. Genomics (2007) [Pubmed]
  9. Genes coding for the elongation factor EF-1 alpha in Artemia. Lenstra, J.A., Van Vliet, A., Arnberg, A.C., Van Hemert, F.J., Möller, W. Eur. J. Biochem. (1986) [Pubmed]
  10. Purification of P-TEFb, a transcription factor required for the transition into productive elongation. Marshall, N.F., Price, D.H. J. Biol. Chem. (1995) [Pubmed]
  11. Identification of endogenous substrates for Drosophila calpain from a salt-extracted fraction of Drosophila ovaries. Amano, S., Kawasaki, H., Ishiura, S., Kawashima, S., Suzuki, K., Emori, Y. J. Biochem. (1997) [Pubmed]
  12. Isolation and characterization of the gene encoding the Drosophila melanogaster transcriptional elongation factor, TFIIS. Oh, Y., Yoon, J., Baek, K. Biochim. Biophys. Acta (1995) [Pubmed]
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