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Gene Review:

PIK3C2G - phosphatidylinositol-4-phosphate 3-kinase,...

Homo sapiens

Synonyms: PI3K-C2-gamma, PI3K-C2GAMMA, Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit gamma, Phosphoinositide 3-kinase-C2-gamma, PtdIns-3-kinase C2 subunit gamma

Rozycka, M. et al., Traer, C.J. et al., Misawa, H. et al., Lambros, M.B. et al.

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High impact information on PIK3C2G

Other potential oncogenes, which mapped to regions found by this study, included cyclin E and PIK3C2G [1].
PIK3C2G was mapped to chromosome 12 at 12p12 by fluorescence in situ hybridization [2].
cDNA cloning of a third human C2-domain-containing class II phosphoinositide 3-kinase, PI3K-C2gamma, and chromosomal assignment of this gene (PIK3C2G) to 12p12 [2].
Unlike other Class II PI3Ks, PI3K-C2 gamma exclusively expressed in the liver, and a N-terminal truncated form was found in lung and a certain hematopoietic cell line [3].
Of the three classes of true phosphoinositide (PI) 3-kinases, the class II subdivision, which consists of three isoforms, PI3K-C2alpha, PI3K-C2beta and PI3K-C2gamma, is the least well understood [4].

References

Analysis of ovarian cancer cell lines using array-based comparative genomic hybridization. Lambros, M.B., Fiegler, H., Jones, A., Gorman, P., Roylance, R.R., Carter, N.P., Tomlinson, I.P. J. Pathol. (2005) [Pubmed]
cDNA cloning of a third human C2-domain-containing class II phosphoinositide 3-kinase, PI3K-C2gamma, and chromosomal assignment of this gene (PIK3C2G) to 12p12. Rozycka, M., Lu, Y.J., Brown, R.A., Lau, M.R., Shipley, J.M., Fry, M.J. Genomics (1998) [Pubmed]
Cloning and characterization of a novel class II phosphoinositide 3-kinase containing C2 domain. Misawa, H., Ohtsubo, M., Copeland, N.G., Gilbert, D.J., Jenkins, N.A., Yoshimura, A. Biochem. Biophys. Res. Commun. (1998) [Pubmed]
Are class II phosphoinositide 3-kinases potential targets for anticancer therapies? Traer, C.J., Foster, F.M., Abraham, S.M., Fry, M.J. Bulletin du cancer. (2006) [Pubmed]

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PIK3C2G	Bos taurus
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pik3c2g	Danio rerio
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Pik3c2g	Mus musculus
PIK3C2G	Pan troglodytes
Pik3c2g	Rattus norvegicus

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