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Gene Review

ACXA  -  CG17176 gene product from transcript...

Drosophila melanogaster

Synonyms: AC, AC62D, Ac62D, CG17176, DACXA, ...
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High impact information on ACXA

  • We have generated transgenic mice in which the expression of a constitutively active form of G(s)alpha (G(s)alpha* Q227L), the G protein that stimulates adenylyl cyclase activity, is driven in neurons within the forebrain by the promoter from the CaMKIIalpha gene [1].
  • Despite significantly increased adenylyl cyclase activity, G(s)alpha* transgenic mice exhibit PKA-dependent decreases in levels of cAMP due to a compensatory up-regulation in phosphodiesterase activity [1].


  1. Chronically increased Gs{alpha} signaling disrupts associative and spatial learning. Bourtchouladze, R., Patterson, S.L., Kelly, M.P., Kreibich, A., Kandel, E.R., Abel, T. Learn. Mem. (2006) [Pubmed]
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