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IL20RA  -  interleukin 20 receptor, alpha

Homo sapiens

Synonyms: CRF2-8, Cytokine receptor class-II member 8, Cytokine receptor family 2 member 8, IL-20 receptor subunit alpha, IL-20R-alpha, ...
 
 
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High impact information on IL20RA

  • Therefore, the ability to respond to IL-26 is restricted by the expression of IL-20R1 [1].
  • IL-10R2 is broadly expressed on a wide variety of tissues, whereas only a limited number of tissues express IL-20R1 [1].
  • In addition, there is no apparent correlation between patterns of expression of IL-20R1, IL-20R2, and IL-22R mRNA and susceptibility to Ad.mda-7 in different cell lines [2].
  • Keratinocytes expressed both receptor complexes; however, the expression of IL-22R1 was 10 times higher than that of IL-20R1 [3].
  • The expression of IL-20R1 and IL-20R2 was also upregulated by human umbilical vein endothelial cells in response to hypoxic treatment [4].

References

  1. Cutting edge: IL-26 signals through a novel receptor complex composed of IL-20 receptor 1 and IL-10 receptor 2. Sheikh, F., Baurin, V.V., Lewis-Antes, A., Shah, N.K., Smirnov, S.V., Anantha, S., Dickensheets, H., Dumoutier, L., Renauld, J.C., Zdanov, A., Donnelly, R.P., Kotenko, S.V. J. Immunol. (2004) [Pubmed]
  2. Mda-7/IL-24 induces apoptosis of diverse cancer cell lines through JAK/STAT-independent pathways. Sauane, M., Gopalkrishnan, R.V., Lebedeva, I., Mei, M.X., Sarkar, D., Su, Z.Z., Kang, D.C., Dent, P., Pestka, S., Fisher, P.B. J. Cell. Physiol. (2003) [Pubmed]
  3. Interleukin (IL)-19, IL-20 and IL-24 are produced by and act on keratinocytes and are distinct from classical ILs. Kunz, S., Wolk, K., Witte, E., Witte, K., Doecke, W.D., Volk, H.D., Sterry, W., Asadullah, K., Sabat, R. Exp. Dermatol. (2006) [Pubmed]
  4. IL-20 is expressed in atherosclerosis plaques and promotes atherosclerosis in apolipoprotein E-deficient mice. Chen, W.Y., Cheng, B.C., Jiang, M.J., Hsieh, M.Y., Chang, M.S. Arterioscler. Thromb. Vasc. Biol. (2006) [Pubmed]
 
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