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Gene Review

IL20RB  -  interleukin 20 receptor beta

Homo sapiens

Synonyms: DIRS1, FNDC6, Fibronectin type III domain containing 6, IL-20 receptor subunit beta, IL-20R-beta, ...
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Disease relevance of IL20RB


High impact information on IL20RB

  • IL-23 stimulates epidermal hyperplasia via TNF and IL-20R2-dependent mechanisms with implications for psoriasis pathogenesis [1].
  • Here, we show that mda-7 and IL-19 bind to the previously described IL-20R complex, composed by cytokine receptor family 2-8/IL-20Ralpha and DIRS1/IL-20Rbeta (type I IL-20R) [2].
  • The presence of lambda-recombinase-like genes in DIRS1 elements also accounts for the lack of target-site duplications for these elements and may be related to the unusual structures of their terminal repeats [3].
  • We also present evidence for the existence of DIRS1-like sequences in the human genome [3].
  • IFNalpha/beta enhance the secretion and expression of IL-6 and IL-10 during the response to LPS, but also the up-regulation of IL-20R2 expression [4].

Biological context of IL20RB

  • PAT and kangaroo both contain split direct repeat (SDR) termini, and here we show that DIRS-1 and DrDIRS1 elements contain terminal features structurally related to SDRs [5].

Anatomical context of IL20RB

  • In addition, there is no apparent correlation between patterns of expression of IL-20R1, IL-20R2, and IL-22R mRNA and susceptibility to Ad.mda-7 in different cell lines [6].
  • BACKGROUND: Interleukin (IL)-19, a member of the IL-10 family, signals through the IL-20R1/IL-20R2 heterodimer, which is shown to be involved in abnormal keratinocyte differentiation and proliferation [7].
  • The expression of IL-20R1 and IL-20R2 was also upregulated by human umbilical vein endothelial cells in response to hypoxic treatment [8].

Associations of IL20RB with chemical compounds


Physical interactions of IL20RB

  • The absence of either R1 chain for the two types of receptor complexes for these cytokines (IL-20R1/IL-20R2 and IL-22R1/IL-20R2) on immune cells implies that they cannot act on these cells [10].

Regulatory relationships of IL20RB


Other interactions of IL20RB

  • It has also been shown that in the case of IL-19 and IL-20, IL-20R2 rather than IL-20R1 is a high-affinity receptor chain [12].


  1. IL-23 stimulates epidermal hyperplasia via TNF and IL-20R2-dependent mechanisms with implications for psoriasis pathogenesis. Chan, J.R., Blumenschein, W., Murphy, E., Diveu, C., Wiekowski, M., Abbondanzo, S., Lucian, L., Geissler, R., Brodie, S., Kimball, A.B., Gorman, D.M., Smith, K., de Waal Malefyt, R., Kastelein, R.A., McClanahan, T.K., Bowman, E.P. J. Exp. Med. (2006) [Pubmed]
  2. Cutting edge: STAT activation by IL-19, IL-20 and mda-7 through IL-20 receptor complexes of two types. Dumoutier, L., Leemans, C., Lejeune, D., Kotenko, S.V., Renauld, J.C. J. Immunol. (2001) [Pubmed]
  3. The DIRS1 group of retrotransposons. Goodwin, T.J., Poulter, R.T. Mol. Biol. Evol. (2001) [Pubmed]
  4. The murine liver is a potential target organ for IL-19, IL-20 and IL-24: Type I Interferons and LPS regulate the expression of IL-20R2. Wegenka, U.M., Dikopoulos, N., Reimann, J., Adler, G., Wahl, C. J. Hepatol. (2007) [Pubmed]
  5. kangaroo, a mobile element from Volvox carteri, is a member of a newly recognized third class of retrotransposons. Duncan, L., Bouckaert, K., Yeh, F., Kirk, D.L. Genetics (2002) [Pubmed]
  6. Mda-7/IL-24 induces apoptosis of diverse cancer cell lines through JAK/STAT-independent pathways. Sauane, M., Gopalkrishnan, R.V., Lebedeva, I., Mei, M.X., Sarkar, D., Su, Z.Z., Kang, D.C., Dent, P., Pestka, S., Fisher, P.B. J. Cell. Physiol. (2003) [Pubmed]
  7. Interleukin-19 upregulates keratinocyte growth factor and is associated with psoriasis. Li, H.H., Lin, Y.C., Chen, P.J., Hsiao, C.H., Lee, J.Y., Chen, W.C., Tzung, T.Y., Wu, J.C., Chang, M.S. Br. J. Dermatol. (2005) [Pubmed]
  8. IL-20 is expressed in atherosclerosis plaques and promotes atherosclerosis in apolipoprotein E-deficient mice. Chen, W.Y., Cheng, B.C., Jiang, M.J., Hsieh, M.Y., Chang, M.S. Arterioscler. Thromb. Vasc. Biol. (2006) [Pubmed]
  9. DIRS-1 and the other tyrosine recombinase retrotransposons. Poulter, R.T., Goodwin, T.J. Cytogenet. Genome Res. (2005) [Pubmed]
  10. Interleukin (IL)-19, IL-20 and IL-24 are produced by and act on keratinocytes and are distinct from classical ILs. Kunz, S., Wolk, K., Witte, E., Witte, K., Doecke, W.D., Volk, H.D., Sterry, W., Asadullah, K., Sabat, R. Exp. Dermatol. (2006) [Pubmed]
  11. Expression patterns of IL-10 ligand and receptor gene families provide leads for biological characterization. Nagalakshmi, M.L., Murphy, E., McClanahan, T., de Waal Malefyt, R. Int. Immunopharmacol. (2004) [Pubmed]
  12. Structural features of the interleukin-10 family of cytokines. Zdanov, A. Curr. Pharm. Des. (2004) [Pubmed]
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