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Gene Review

IL26  -  interleukin 26

Homo sapiens

Synonyms: AK155, IL-26, Interleukin-26, Protein AK155
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Disease relevance of IL26


Psychiatry related information on IL26


High impact information on IL26

  • The receptor for IL-26 (AK155), a cytokine of the IL-10 family, has not previously been defined [3].
  • Therefore, the ability to respond to IL-26 is restricted by the expression of IL-20R1 [3].
  • One of these factors, AK155 or IL-26, was discovered because of its overexpression in human T lymphocytes after growth transformation by the simian rhadinovirus herpesvirus saimiri [4].
  • RESULTS: Marker D12S2510, which is located 3 kb 3' from the IL-26 gene, was significantly associated with RA in women (corrected P [P(corr)] = 0.008, 2 degrees of freedom [2 df]) but not in men (P = 0.99, 2 df) [2].
  • IL-22 and IL-26 (AK155) expression was exclusively detected in T cells, especially upon type 1 polarization, and in NK cells [5].

Biological context of IL26


Anatomical context of IL26

  • Regarding T cells, IL-26 was primarily produced by memory cells, and its expression was independent on costimulation [5].

Other interactions of IL26


  1. Interleukin-26. Fickenscher, H., Pirzer, H. Int. Immunopharmacol. (2004) [Pubmed]
  2. Polymorphisms in the interferon-gamma/interleukin-26 gene region contribute to sex bias in susceptibility to rheumatoid arthritis. Vandenbroeck, K., Cunningham, S., Goris, A., Alloza, I., Heggarty, S., Graham, C., Bell, A., Rooney, M. Arthritis Rheum. (2003) [Pubmed]
  3. Cutting edge: IL-26 signals through a novel receptor complex composed of IL-20 receptor 1 and IL-10 receptor 2. Sheikh, F., Baurin, V.V., Lewis-Antes, A., Shah, N.K., Smirnov, S.V., Anantha, S., Dickensheets, H., Dumoutier, L., Renauld, J.C., Zdanov, A., Donnelly, R.P., Kotenko, S.V. J. Immunol. (2004) [Pubmed]
  4. The T-cell lymphokine interleukin-26 targets epithelial cells through the interleukin-20 receptor 1 and interleukin-10 receptor 2 chains. Hör, S., Pirzer, H., Dumoutier, L., Bauer, F., Wittmann, S., Sticht, H., Renauld, J.C., de Waal Malefyt, R., Fickenscher, H. J. Biol. Chem. (2004) [Pubmed]
  5. Cutting edge: immune cells as sources and targets of the IL-10 family members? Wolk, K., Kunz, S., Asadullah, K., Sabat, R. J. Immunol. (2002) [Pubmed]
  6. IL-10 subfamily members: IL-19, IL-20, IL-22, IL-24 and IL-26. Conti, P., Kempuraj, D., Frydas, S., Kandere, K., Boucher, W., Letourneau, R., Madhappan, B., Sagimoto, K., Christodoulou, S., Theoharides, T.C. Immunol. Lett. (2003) [Pubmed]
  7. Investigation of malaria susceptibility determinants in the IFNG/IL26/IL22 genomic region. Koch, O., Rockett, K., Jallow, M., Pinder, M., Sisay-Joof, F., Kwiatkowski, D. Genes Immun. (2005) [Pubmed]
  8. Novel polymorphisms in the IL-10 related AK155 gene (chromosome 12q15). Goris, A., Marrosu, M.G., Vandenbroeck, K. Genes Immun. (2001) [Pubmed]
  9. Induction of a novel cellular homolog of interleukin-10, AK155, by transformation of T lymphocytes with herpesvirus saimiri. Knappe, A., Hör, S., Wittmann, S., Fickenscher, H. J. Virol. (2000) [Pubmed]
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