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Gene Review

Ear3  -  eosinophil-associated, ribonuclease A...

Mus musculus

Synonyms: Eosinophil cationic-type ribonuclease 3, MR-3, Rnase3, mR3, murine ribonuclease 3
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High impact information on Ear3

  • Mutation of site C reduced transcription by 50 and 80%, respectively, in HepG2 and Caco-2 cells, and electrophoretic mobility shift assays showed that nuclear hormone receptors, including ARP-1 and its homologue Ear-3/COUP-TF, were occupants of site C in both of these cell types [1].
  • Three of these genes (mR-3, mR-4, mR-5) include complete open reading frames, encoding ribonucleases with eight cysteines and appropriately spaced histidines (His11 and His124) and lysine (Lys35) that are characteristic of this enlarging protein family; the fourth sequence encodes a non-functional pseudogene (mR-6P) [2].


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