Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Gene Review:

Ear3 - eosinophil-associated, ribonuclease A...

Mus musculus

Synonyms: Eosinophil cationic-type ribonuclease 3, MR-3, Rnase3, mR3, murine ribonuclease 3

Batten, D. et al., Gaudet, F. et al.

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High impact information on Ear3

Mutation of site C reduced transcription by 50 and 80%, respectively, in HepG2 and Caco-2 cells, and electrophoretic mobility shift assays showed that nuclear hormone receptors, including ARP-1 and its homologue Ear-3/COUP-TF, were occupants of site C in both of these cell types [1].
Three of these genes (mR-3, mR-4, mR-5) include complete open reading frames, encoding ribonucleases with eight cysteines and appropriately spaced histidines (His11 and His124) and lysine (Lys35) that are characteristic of this enlarging protein family; the fourth sequence encodes a non-functional pseudogene (mR-6P) [2].

References

Transcriptional regulation of the cholesteryl ester transfer protein gene by the orphan nuclear hormone receptor apolipoprotein AI regulatory protein-1. Gaudet, F., Ginsburg, G.S. J. Biol. Chem. (1995) [Pubmed]
Molecular cloning of four novel murine ribonuclease genes: unusual expansion within the ribonuclease A gene family. Batten, D., Dyer, K.D., Domachowske, J.B., Rosenberg, H.F. Nucleic Acids Res. (1997) [Pubmed]

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