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Gene Review:

Ear4 - eosinophil-associated, ribonuclease A...

Mus musculus

Synonyms: Eosinophil cationic-type ribonuclease 4, MR-4, Non-secretory ribonuclease, RNS2, RNase 2, ...

Niles, R.M. et al., Batten, D. et al., Toppel, A.W. et al., Yu, C. et al.

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High impact information on Ear4

However, cholate still strongly induced phospho-JNK in mR4(-/-) livers [1].
Three of these genes (mR-3, mR-4, mR-5) include complete open reading frames, encoding ribonucleases with eight cysteines and appropriately spaced histidines (His11 and His124) and lysine (Lys35) that are characteristic of this enlarging protein family; the fourth sequence encodes a non-functional pseudogene (mR-6P) [2].
The isogenic mutant of KTL3, MR4, devoid of surface-bound GRAB, was attenuated in virulence, compared with the wild-type strain [3].
The protein kinase from both cell types was stimulated by cyclic AMP, but the level of MR-4 kinase activity at maximal cyclic AMP concentrations remained considerably lower than B-16 F1 kinase activity under the same conditions [4].

Associations of Ear4 with chemical compounds

Although the variant (MR-4) was completely resistant to growth inhibition of MSH, cyclic AMP was still able to block cell replication [4].

References

Independent repression of bile acid synthesis and activation of c-Jun N-terminal kinase (JNK) by activated hepatocyte fibroblast growth factor receptor 4 (FGFR4) and bile acids. Yu, C., Wang, F., Jin, C., Huang, X., McKeehan, W.L. J. Biol. Chem. (2005) [Pubmed]
Molecular cloning of four novel murine ribonuclease genes: unusual expansion within the ribonuclease A gene family. Batten, D., Dyer, K.D., Domachowske, J.B., Rosenberg, H.F. Nucleic Acids Res. (1997) [Pubmed]
Contribution of protein G-related alpha2-macroglobulin-binding protein to bacterial virulence in a mouse skin model of group A streptococcal infection. Toppel, A.W., Rasmussen, M., Rohde, M., Medina, E., Chhatwal, G.S. J. Infect. Dis. (2003) [Pubmed]
Isolation and characterization of a variant of B16-mouse melanoma resistant to MSH growth inhibition. Niles, R.M., Logue, M.P. J. Supramol. Struct. (1979) [Pubmed]

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