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MeSH Review

Caco-2 Cells

 
 
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Disease relevance of Caco-2 Cells

 

High impact information on Caco-2 Cells

  • We found that Caco-2 cells are capable of dose-dependent, facilitated transcytosis of SEB and TSST-1, but not SEA [6].
  • Apical (but not basolateral) leptin increased Caco-2 cell transport of cephalexin (CFX) and glycylsarcosine (Gly-Sar), an effect that was associated with increased Gly-Sar uptake, increased membrane PepT1 protein, decreased intracellular PepT1 content, and no change in PepT1 mRNA levels [7].
  • In accordance with this suggestion, treatment of Caco-2 cells with cholera toxin, which elevated intracellular cAMP levels, was found to inhibit taurine uptake [1].
  • STa caused a 21-fold increase in guanosine 3',5'-cyclic monophosphate (cGMP) levels in Caco-2 cells with no change in cAMP levels [1].
  • METHODS: Interleukin-1beta-stimulated Caco-2 cells were exposed basolaterally to nanomolar concentrations of activated MMP-3 or cocultured with interleukin-1beta-stimulated, MMP-producing, colonic myofibroblasts (CCD-18co) [8].
 

Chemical compound and disease context of Caco-2 Cells

 

Biological context of Caco-2 Cells

 

Anatomical context of Caco-2 Cells

 

Associations of Caco-2 Cells with chemical compounds

 

Gene context of Caco-2 Cells

 

Analytical, diagnostic and therapeutic context of Caco-2 Cells

References

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  2. Opposite polarity of virus budding and of viral envelope glycoprotein distribution in epithelial cells derived from different tissues. Zurzolo, C., Polistina, C., Saini, M., Gentile, R., Aloj, L., Migliaccio, G., Bonatti, S., Nitsch, L. J. Cell Biol. (1992) [Pubmed]
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  16. Butyrate mediates Caco-2 cell apoptosis via up-regulation of pro-apoptotic BAK and inducing caspase-3 mediated cleavage of poly-(ADP-ribose) polymerase (PARP). Ruemmele, F.M., Dionne, S., Qureshi, I., Sarma, D.S., Levy, E., Seidman, E.G. Cell Death Differ. (1999) [Pubmed]
  17. Monocyte-chemoattractant protein 1 gene expression in intestinal epithelial cells and inflammatory bowel disease mucosa. Reinecker, H.C., Loh, E.Y., Ringler, D.J., Mehta, A., Rombeau, J.L., MacDermott, R.P. Gastroenterology (1995) [Pubmed]
  18. Polarized secretion of diamine oxidase by intestinal epithelial cells and its stimulation by heparin. Daniele, B., Quaroni, A. Gastroenterology (1990) [Pubmed]
  19. H+/amino acid transporter 1 (PAT1) is the imino acid carrier: An intestinal nutrient/drug transporter in human and rat. Anderson, C.M., Grenade, D.S., Boll, M., Foltz, M., Wake, K.A., Kennedy, D.J., Munck, L.K., Miyauchi, S., Taylor, P.M., Campbell, F.C., Munck, B.G., Daniel, H., Ganapathy, V., Thwaites, D.T. Gastroenterology (2004) [Pubmed]
  20. Progressive familial intrahepatic cholestasis, type 1, is associated with decreased farnesoid X receptor activity. Chen, F., Ananthanarayanan, M., Emre, S., Neimark, E., Bull, L.N., Knisely, A.S., Strautnieks, S.S., Thompson, R.J., Magid, M.S., Gordon, R., Balasubramanian, N., Suchy, F.J., Shneider, B.L. Gastroenterology (2004) [Pubmed]
  21. Gastrointestinal glutathione peroxidase prevents transport of lipid hydroperoxides in CaCo-2 cells. Wingler, K., Müller, C., Schmehl, K., Florian, S., Brigelius-Flohé, R. Gastroenterology (2000) [Pubmed]
  22. High-density lipoprotein 3 retroendocytosis: a new lipoprotein pathway in the enterocyte (Caco-2). Rogler, G., Herold, G., Fahr, C., Fahr, M., Rogler, D., Reimann, F.M., Stange, E.F. Gastroenterology (1992) [Pubmed]
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  24. Relation between integrin alpha7Bbeta1 expression in human intestinal cells and enterocytic differentiation. Basora, N., Vachon, P.H., Herring-Gillam, F.E., Perreault, N., Beaulieu, J.F. Gastroenterology (1997) [Pubmed]
  25. Omega 3-lipid peroxides injure CaCo-2 cells: relationship to the development of reduced glutathione antioxidant systems. Cepinskas, G., Kvietys, P.R., Aw, T.Y. Gastroenterology (1994) [Pubmed]
  26. Lysophosphatidylcholine increases 3-Hydroxy-3-methylglutaryl-coenzyme A reductase gene expression in CaCo-2 cells. Muir, L.V., Born, E., Mathur, S.N., Field, F.J. Gastroenterology (1996) [Pubmed]
  27. Heparan sulfate/heparin oligosaccharides protect stromal cell-derived factor-1 (SDF-1)/CXCL12 against proteolysis induced by CD26/dipeptidyl peptidase IV. Sadir, R., Imberty, A., Baleux, F., Lortat-Jacob, H. J. Biol. Chem. (2004) [Pubmed]
  28. Transcriptional induction of CYP1A1 by oltipraz in human Caco-2 cells is aryl hydrocarbon receptor- and calcium-dependent. Le Ferrec, E., Lagadic-Gossmann, D., Rauch, C., Bardiau, C., Maheo, K., Massiere, F., Le Vee, M., Guillouzo, A., Morel, F. J. Biol. Chem. (2002) [Pubmed]
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  32. cAMP-mediated inhibition of the epithelial brush border Na+/H+ exchanger, NHE3, requires an associated regulatory protein. Yun, C.H., Oh, S., Zizak, M., Steplock, D., Tsao, S., Tse, C.M., Weinman, E.J., Donowitz, M. Proc. Natl. Acad. Sci. U.S.A. (1997) [Pubmed]
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