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Gene Review:

vps33b - vacuolar protein sorting 33B

Danio rerio

Synonyms: SO:0000704, Vacuolar protein sorting-associated protein 33B

Matthews, R.P. et al.

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High impact information on vps33b

Biliary defects in vps33b-deficient zebrafish larvae closely resemble the bile duct paucity associated with knockdown of the onecut transcription factor hnf6 [1].
Zebrafish vhnf1, but not hnf6, increases vps33b expression in zebrafish embryos and in mammalian liver cells [1].
Knockdown of vps33b causes bile duct paucity and impairs intestinal lipid absorption, thus phenocopying digestive defects characteristic of ARC [1].

Analytical, diagnostic and therapeutic context of vps33b

Electrophoretic mobility shift assays suggest that this regulation occurs through direct binding of vHnf1 to the vps33b promoter [1].

References

Zebrafish vps33b, an ortholog of the gene responsible for human arthrogryposis-renal dysfunction-cholestasis syndrome, regulates biliary development downstream of the onecut transcription factor hnf6. Matthews, R.P., Plumb-Rudewiez, N., Lorent, K., Gissen, P., Johnson, C.A., Lemaigre, F., Pack, M. Development (2005) [Pubmed]

Contributions to this collaborative article are from individual authors of WikiGenes or mined by the WikiGenes Data Mining Engine from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.About WikiGenes Open Access Licence Privacy Policy Terms of Use apsburg

VPS33B	Bos taurus
vps-33.2	Caenorhabditis elegans
VPS33B	Canis lupus familiaris
VPS33B	Gallus gallus
VPS33B	Homo sapiens
VPS33B	Macaca mulatta
Vps33b	Mus musculus
VPS33B	Pan troglodytes
Vps33b	Rattus norvegicus
vps33b	Xenopus (Silurana) tropicalis

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