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Gene Review:

Itpkb - inositol-trisphosphate 3-kinase B

Rattus norvegicus

Synonyms: IP3 3-kinase B, IP3K B, Inositol 1,4,5-trisphosphate 3-kinase B, Inositol-trisphosphate 3-kinase B, InsP 3-kinase B

Soriano, S. et al., Thomas, S. et al., Thomas, S. et al.

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High impact information on Itpkb

However, soluble, calmodulin-binding non-fusion IP3 3-kinase B is enzymically inactive [1].
Possible roles of inositol 1,4,5-trisphosphate 3-kinase B in calcium homeostasis [2].
Sequence comparison shows it (i) to be 93% identical to human hippocampus IP3 3-kinase B over 468 residues at the protein level, and (ii) to encode a protein 204 amino acids larger than the published sequence of its human homologue [3].

Associations of Itpkb with chemical compounds

Some aspects of the roles of inositol trisphosphate (Insp3) and inositol tetrakisphosphate (Insp4) in Ca2+ homeostasis in terms of inositol trisphosphate 3-kinase B (IP3K-B) localization and activity are discussed [2].

References

Expression of recombinant rat myo-inositol 1,4,5-trisphosphate 3-kinase B suggests a regulatory role for its N-terminus. Thomas, S., Soriano, S., d'Santos, C., Banting, G. Biochem. J. (1996) [Pubmed]
Possible roles of inositol 1,4,5-trisphosphate 3-kinase B in calcium homeostasis. Soriano, S., Banting, G. FEBS Lett. (1997) [Pubmed]
Isolation and sequence of a full length cDNA encoding a novel rat inositol 1,4,5-trisphosphate 3-kinase. Thomas, S., Brake, B., Luzio, J.P., Stanley, K., Banting, G. Biochim. Biophys. Acta (1994) [Pubmed]

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ITPKB	Bos taurus
ITPKB	Canis lupus familiaris
itpkb	Danio rerio
IP3K2	Drosophila melanogaster
ITPKB	Gallus gallus
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itpkb	Xenopus (Silurana) tropicalis

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