High impact information on Smgb

• Psp and Smgb are regulated similarly in the developing submandibular gland, but differently in the sublingual and parotid glands [1].
• However, no evidence for proteins derived from an Smgb-like gene was observed in neonatal mouse submandibular or sublingual glands [1].
• In addition to the previously observed sequence similarity, Psp and Smgb are highly homologous throughout exon 1 and at 365 of 600bp immediately upstream of the transcription start site [2].

Biological context of Smgb

• While Psp is expressed similarly in the mouse, the putative Smgb gene of the mouse seems not to be expressed, apparently due to the insertion, between exons 1 and 2, of a gene for a retroviral protein [3].

Anatomical context of Smgb

• Psp and Smgb: a model for developmental and functional regulation in the rat major salivary glands [3].

References