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MeSH Review

Sublingual Gland

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Disease relevance of Sublingual Gland


High impact information on Sublingual Gland

  • We have purified and characterized the blarina toxin (BLTX), a lethal mammalian venom with a tissue kallikrein-like activity from the submaxillary and sublingual glands of the short-tailed shrew Blarina brevicauda [3].
  • Moreover, one part of this peptide is identical to the 196-amino acid sequence deduced from the cDNA clone pSM2-1, which codes for a part of the high molecular weight mucin MG1 isolated from human sublingual gland [4].
  • Morphologic changes were less marked in the sublingual glands, although mucin levels were noticeably depressed by Day 12 of deficiency [5].
  • Following the oral dosing of deficient animals (T12) with 350 micrograms retinyl palmitate, all such changes were reversed within 6 days in the trachea and within 10 days in the submaxillary and sublingual glands [5].
  • Alkaline borohydride reductive cleavage of the major glycoprotein fraction of rat sublingual gland resulted in the release of a series of reduced oligosaccharides [6].

Biological context of Sublingual Gland


Anatomical context of Sublingual Gland


Associations of Sublingual Gland with chemical compounds


Gene context of Sublingual Gland

  • However, no evidence for proteins derived from an Smgb-like gene was observed in neonatal mouse submandibular or sublingual glands [20].
  • Previously, we isolated a clone (pSM2-1) from a human sublingual gland cDNA expression library using an antibody against deglycosylated MG1 (Troxler et al., Biochem. Biophys. Res Commun., 217, 1112-1119, 1995) [21].
  • Northern blot analysis also demonstrated that MUC7 is not expressed in the submandibular/sublingual gland complexes of hamster, mouse and rat [22].
  • Examination of Nkx2-3 null mice revealed defects in maturation and cellular organisation of the sublingual glands [23].
  • Comparative Northern analyses between the major salivary glands demonstrate highly selective Muc19 expression in neonatal and adult sublingual glands, whereas Smgc is expressed in neonatal submandibular and sublingual glands [24].

Analytical, diagnostic and therapeutic context of Sublingual Gland


  1. Primary localization amyloidosis of the sublingual gland. Kurokawa, H., Takuma, C., Tokudome, S., Yamashita, Y., Kajiyama, M. Fukuoka Igaku Zasshi (1998) [Pubmed]
  2. Cervical ranulas. Batsakis, J.G., McClatchey, K.D. The Annals of otology, rhinology, and laryngology. (1988) [Pubmed]
  3. Blarina toxin, a mammalian lethal venom from the short-tailed shrew Blarina brevicauda: Isolation and characterization. Kita, M., Nakamura, Y., Okumura, Y., Ohdachi, S.D., Oba, Y., Yoshikuni, M., Kido, H., Uemura, D. Proc. Natl. Acad. Sci. U.S.A. (2004) [Pubmed]
  4. Genomic organization of the 3' region of the human mucin gene MUC5B. Desseyn, J.L., Aubert, J.P., Van Seuningen, I., Porchet, N., Laine, A. J. Biol. Chem. (1997) [Pubmed]
  5. Morphologic alterations in the trachea and the salivary gland following the induction of rapid synchronous vitamin A deficiency in rats. Anzano, M.A., Olson, J.A., Lamb, A.J. Am. J. Pathol. (1980) [Pubmed]
  6. Structures of the acidic oligosaccharides isolated from rat sublingual glycoprotein. Slomiany, A., Slomiany, B.L. J. Biol. Chem. (1978) [Pubmed]
  7. The effects of epinephrine, norepinephrine, and carbachol on oxygen consumption in rat sublingual gland slices. Terzić, M., Stojić, D. J. Dent. Res. (1984) [Pubmed]
  8. Role of amino acids in salivation and the localization of their receptors in the rat salivary gland. Shida, T., Kondo, E., Ueda, Y., Takai, N., Yoshida, Y., Araki, T., Kiyama, H., Tohyama, M. Brain Res. Mol. Brain Res. (1995) [Pubmed]
  9. Chronic alcohol ingestion enhances tumor necrosis factor-alpha expression and salivary gland apoptosis. Slomiany, B.L., Piotrowski, J., Slomiany, A. Alcohol. Clin. Exp. Res. (1997) [Pubmed]
  10. Molecular cloning of a novel high molecular weight mucin (MG1) from human sublingual gland. Troxler, R.F., Offner, G.D., Zhang, F., Iontcheva, I., Oppenheim, F.G. Biochem. Biophys. Res. Commun. (1995) [Pubmed]
  11. Developmental studies on vasoactive intestinal peptide, substance P and calcitonin gene-related peptide in salivary glands of postnatal rats. Ekström, J., Ekman, R., Håkanson, R., Luts, A., Sundler, F. Acta Physiol. Scand. (1994) [Pubmed]
  12. MUC5B is a major gel-forming, oligomeric mucin from human salivary gland, respiratory tract and endocervix: identification of glycoforms and C-terminal cleavage. Wickström, C., Davies, J.R., Eriksen, G.V., Veerman, E.C., Carlstedt, I. Biochem. J. (1998) [Pubmed]
  13. A comparison of serine and threonine O-glycosylation by UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase. O'Connell, B.C., Tabak, L.A. J. Dent. Res. (1993) [Pubmed]
  14. Differential activation of nitric oxide synthase through muscarinic acetylcholine receptors in rat salivary glands. Leirós, C.P., Rosignoli, F., Genaro, A.M., Sales, M.E., Sterin-Borda, L., Santiago BordaE, n.u.l.l. J. Auton. Nerv. Syst. (2000) [Pubmed]
  15. Monoclonal antibodies to the Golgi apparatus of serous exocrine cells. Yamashita, S., Uchida, H., Shiozawa, M., Aiso, S., Yasuda, K. J. Histochem. Cytochem. (1993) [Pubmed]
  16. Aquaporin-5 (AQP5), a water channel protein, in the rat salivary and lacrimal glands: immunolocalization and effect of secretory stimulation. Matsuzaki, T., Suzuki, T., Koyama, H., Tanaka, S., Takata, K. Cell Tissue Res. (1999) [Pubmed]
  17. Cyclic AMP in the sublingual glands of the mouse. Amerongen, A.V., Roukema, P.A., Vreugdenhil, A.P. J. Physiol. (Lond.) (1980) [Pubmed]
  18. Iodothyronine 5'-deiodinase is present in mouse sublingual gland. Tanaka, K., Imura, H. Endocrinology (1993) [Pubmed]
  19. Comparative developmental analysis of the parotid, submandibular and sublingual glands in the neonatal rat. Humphreys-Beher, M.G., Hollis, D.L., Carlson, D.M. Biochem. J. (1982) [Pubmed]
  20. Characterization of the rat salivary-gland B1-immunoreactive proteins. Mirels, L., Miranda, A.J., Ball, W.D. Biochem. J. (1998) [Pubmed]
  21. Molecular characterization of a major high molecular weight mucin from human sublingual gland. Troxler, R.F., Iontcheva, I., Oppenheim, F.G., Nunes, D.P., Offner, G.D. Glycobiology (1997) [Pubmed]
  22. MUC7 gene expression and genetic polymorphism. Biesbrock, A.R., Bobek, L.A., Levine, M.J. Glycoconj. J. (1997) [Pubmed]
  23. NK-2 class homeobox genes and pharyngeal/oral patterning: Nkx2-3 is required for salivary gland and tooth morphogenesis. Biben, C., Wang, C.C., Harvey, R.P. Int. J. Dev. Biol. (2002) [Pubmed]
  24. The gene encoding mouse Muc19: cDNA, genomic organization and relationship to Smgc. Culp, D.J., Latchney, L.R., Fallon, M.A., Denny, P.A., Denny, P.C., Couwenhoven, R.I., Chuang, S. Physiol. Genomics (2004) [Pubmed]
  25. The effect of chronic atropine treatment on salivary composition and caries in rats. Watson, G.E., Pearson, S.K., Falany, J.L., Culp, D.J., Tabak, L.A., Bowen, W.H. J. Dent. Res. (1989) [Pubmed]
  26. Involvement of hepatocyte growth factor in branching morphogenesis of murine salivary gland. Ikari, T., Hiraki, A., Seki, K., Sugiura, T., Matsumoto, K., Shirasuna, K. Dev. Dyn. (2003) [Pubmed]
  27. Basic fibroblast growth factor in rat salivary glands. Amano, O., Yoshitake, Y., Nishikawa, K., Iseki, S. Cell Tissue Res. (1993) [Pubmed]
  28. Autoradiographic localization of transported neutral amino acids in epithelia of cat submandibular and sublingual salivary glands. Mann, G.E., Møller, M., Poulsen, J.H., Wilson, S.M., Yudilevich, D.L. Cell Tissue Res. (1986) [Pubmed]
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