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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

Rassf5  -  Ras association (RalGDS/AF-6) domain...

Rattus norvegicus

Synonyms: Maxp1, New ras effector 1, Nore1, Ras association domain-containing protein 5
 
 
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High impact information on Rassf5

  • Moreover, an analysis of Nore1 protein expression showed that it is frequently down-regulated in lung tumor cell lines and primary lung tumors [1].
  • Like RASSF1, this correlates with methylation of the Nore1 promoter rather than gene deletion [1].
  • We now show that the Ras effector Nore1, which is structurally related to RASSF1, can also mediate a Ras-dependent apoptosis [1].
  • Chromosome mapping and sequence variation of the murine Ras effector gene Nore1 [2].

References

  1. The pro-apoptotic Ras effector Nore1 may serve as a Ras-regulated tumor suppressor in the lung. Vos, M.D., Martinez, A., Ellis, C.A., Vallecorsa, T., Clark, G.J. J. Biol. Chem. (2003) [Pubmed]
  2. Chromosome mapping and sequence variation of the murine Ras effector gene Nore1. Yao, R., Wang, Y., You, M. Cytogenet. Cell Genet. (2001) [Pubmed]
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