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Gene Review

Phc2  -  polyhomeotic-like 2 (Drosophila)

Mus musculus

Synonyms: A3galt2, AA415044, D130050K19Rik, D4Ertd810e, Early development regulatory protein 2, ...
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High impact information on Phc2

  • The genetic interactions further reveal the functional overlap between Phc2 and Phc1 and a strict dose-dependent requirement during A-P specification and embryonic survival [1].
  • In this study, we describe the generation and phenotypes of Phc2-deficient mice [1].
  • Mph2 was identified by serial analysis of gene expression as a differentially expressed gene during cortical development [2].
  • Mph2 expression evident in proliferating precursor cell populations in the developing mouse brain such as the ventricular zones of the cortex and ganglionic eminences as well as in mature structures such as the granule cell layer of the adult dentate gyrus and cerebellum indicates a role for Mph2 in both the developing and adult brain [2].
  • Genomic and RNA analyses have shown that Edr2 locates on Chromosome 4 as a single copy gene and is transcribed into at least two transcript isoforms about 3.0 and 4.4 kb in length, most likely corresponding to the 2.5- and 3.8-kb cDNAs, respectively [3].

Other interactions of Phc2


Analytical, diagnostic and therapeutic context of Phc2


  1. Mammalian polyhomeotic homologues Phc2 and Phc1 act in synergy to mediate polycomb repression of Hox genes. Isono, K., Fujimura, Y., Shinga, J., Yamaki, M., O-Wang, J., Takihara, Y., Murahashi, Y., Takada, Y., Mizutani-Koseki, Y., Koseki, H. Mol. Cell. Biol. (2005) [Pubmed]
  2. Mph2 expression in germinal zones of the mouse brain. Kim, M.H., Gunnersen, J.M., Tan, S.S. Dev. Dyn. (2005) [Pubmed]
  3. The mouse Edr2 (Mph2) gene has two forms of mRNA encoding 90- and 36-kDa polypeptides. Yamaki, M., Isono, K., Takada, Y., Abe, K., Akasaka, T., Tanzawa, H., Koseki, H. Gene (2002) [Pubmed]
  4. Regulation of polyunsaturated fat induced postprandial hypercholesterolemia by a novel gene Phc-2. Vaithilingam, D.S., Antao, V., Kakis, G. Mol. Cell. Biochem. (1994) [Pubmed]
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