Gene Review:
Phc1 - polyhomeotic-like 1 (Drosophila)
Mus musculus
Synonyms:
AW557034, Early development regulatory protein 1, Edr, Edr1, Mph1, ...
- The Polycomb-group gene Rae28 sustains Nkx2.5/Csx expression and is essential for cardiac morphogenesis. Shirai, M., Osugi, T., Koga, H., Kaji, Y., Takimoto, E., Komuro, I., Hara, J., Miwa, T., Yamauchi-Takihara, K., Takihara, Y. J. Clin. Invest. (2002)
- Overexpression of Polycomb-group gene rae28 in cardiomyocytes does not complement abnormal cardiac morphogenesis in mice lacking rae28 but causes dilated cardiomyopathy. Koga, H., Kaji, Y., Nishii, K., Shirai, M., Tomotsune, D., Osugi, T., Sawada, A., Kim, J.Y., Hara, J., Miwa, T., Yamauchi-Takihara, K., Shibata, Y., Takihara, Y. Lab. Invest. (2002)
- Lack of the Polycomb-group gene rae28 causes maturation arrest at the early B-cell developmental stage. Tokimasa, S., Ohta, H., Sawada, A., Matsuda, Y., Kim, J.Y., Nishiguchi, S., Hara, J., Takihara, Y. Exp. Hematol. (2001)
- Dissociation of mammalian Polycomb-group proteins, Ring1B and Rae28/Ph1, from the chromatin correlates with configuration changes of the chromatin in mitotic and meiotic prophase. Miyagishima, H., Isono, K., Fujimura, Y., Iyo, M., Takihara, Y., Masumoto, H., Vidal, M., Koseki, H. Histochem. Cell Biol. (2003)
- The Drosophila Polycomb group gene Sex comb on midleg (Scm) encodes a zinc finger protein with similarity to polyhomeotic protein. Bornemann, D., Miller, E., Simon, J. Development (1996)
- Polycomb group gene rae28 is required for sustaining activity of hematopoietic stem cells. Ohta, H., Sawada, A., Kim, J.Y., Tokimasa, S., Nishiguchi, S., Humphries, R.K., Hara, J., Takihara, Y. J. Exp. Med. (2002)
- Mammalian polyhomeotic homologues Phc2 and Phc1 act in synergy to mediate polycomb repression of Hox genes. Isono, K., Fujimura, Y., Shinga, J., Yamaki, M., O-Wang, J., Takihara, Y., Murahashi, Y., Takada, Y., Mizutani-Koseki, Y., Koseki, H. Mol. Cell. Biol. (2005)
- Targeted disruption of the mouse homologue of the Drosophila polyhomeotic gene leads to altered anteroposterior patterning and neural crest defects. Takihara, Y., Tomotsune, D., Shirai, M., Katoh-Fukui, Y., Nishii, K., Motaleb, M.A., Nomura, M., Tsuchiya, R., Fujita, Y., Shibata, Y., Higashinakagawa, T., Shimada, K. Development (1997)
- Characterization of cis-elements required for the transcriptional activation of the rae28/mph1 gene in F9 cells. Motaleb, M.A., Takihara, Y., Ohta, H., Shimada, K. Biochem. Biophys. Res. Commun. (1999)
- Sequence-specific DNA binding activity in the RAE28 protein, a mouse homologue of the Drosophila polyhomeotic protein. Nomura, M., Takihara, Y., Abdul Motaleb, M., Horie, K., Higashinakagawa, T., Shimada, K. Biochem. Mol. Biol. Int. (1998)
- Structural organization of the rae28 gene, a putative murine homologue of the Drosophila polyhomeotic gene. Abdul Motaleb, M., Takihara, Y., Nomura, M., Matsuda, Y., Higashinakagawa, T., Shimada, K. J. Biochem. (1996)
- Regulation of Hoxb3 expression in the hindbrain and pharyngeal arches by rae28, a member of the mammalian Polycomb group of genes. Tomotsune, D., Shirai, M., Takihara, Y., Shimada, K. Mech. Dev. (2000)
- RAE28, BMI1, and M33 are members of heterogeneous multimeric mammalian Polycomb group complexes. Hashimoto, N., Brock, H.W., Nomura, M., Kyba, M., Hodgson, J., Fujita, Y., Takihara, Y., Shimada, K., Higashinakagawa, T. Biochem. Biophys. Res. Commun. (1998)