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Gene Review:

ADH2 - alcohol dehydrogenase

Solanum lycopersicum

Frenkel, C. et al., van den Berg, B.M., Ingersoll, J.C. et al.

Frenkel, Peters, Tieman, Tiznado, Handa,

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High impact information on LOC544074

In vitro studies indicate that methanol is a competitive inhibitor of the tomato alcohol dehydrogenase (ADH, EC 1.1.1.1) activity suggesting that ADH-catalyzed production of ethanol may be arrested by methanol accumulation in the wild-type but not in the PME mutant where methanol levels remain low [1].
Two novel tandemly-oriented open reading frames (ORFs) with homology to alcohol dehydrogenase (ADH) were isolated from tomato [2].

Analytical, diagnostic and therapeutic context of LOC544074

The method is based on the analysis of the ADH variants by ultrathin-layer isoelectric focusing, pH range 3-10, of crude extracts from imbibed seeds, followed by enzyme activity staining [3].

References

Pectin methylesterase regulates methanol and ethanol accumulation in ripening tomato (Lycopersicon esculentum) fruit. Frenkel, C., Peters, J.S., Tieman, D.M., Tiznado, M.E., Handa, A.K. J. Biol. Chem. (1998) [Pubmed]
A novel anther-expressed adh-homologous gene in Lycopersicon esculentum. Ingersoll, J.C., Rothenberg, M., Liedl, B.E., Folkerts, K., Garvin, D., Hanson, M.R., Doyle, J.J., Mutschler, M.A. Plant Mol. Biol. (1994) [Pubmed]
A rapid and economical method for hybrid purity testing of tomato (Lycopersicon esculentum L.) F1 hybrids using ultrathin-layer isoelectric focusing of alcohol dehydrogenase variants from seeds. van den Berg, B.M. Electrophoresis (1991) [Pubmed]

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