High impact information on UGT2B28

• A novel human UGT2B cDNA of 1666 bp was isolated and encodes a 529-amino acid protein named UGT2B28 type I. Glucuronidation assays demonstrated that UGT2B28 type I catalyzes the conjugation of endogenous and exogenous compounds [1].
• The tissue distribution of UGT2B28 revealed the expression of the type I transcript in the liver, breast, and LNCaP cells [1].
• Isolation and characterization of the UGT2B28 cDNA encoding a novel human steroid conjugating UDP-glucuronosyltransferase [1].
• The expression of UGT2B28 type I in the breast and liver suggests a role of this enzyme in the androgen and estrogen metabolism in these tissues [1].

Other interactions of UGT2B28

• Two other UGT2B cDNAs were isolated, and sequence analysis led to the identification of two truncated UGT2B28 species [1].

References