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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

SGTB  -  small glutamine-rich tetratricopeptide...

Homo sapiens

Synonyms: Beta-SGT, FLJ39002, SGT2, Sgt2, Small glutamine-rich protein with tetratricopeptide repeats 2, ...
 
 
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Disease relevance of SGTB

  • To examine the ability of the mycaminosyltransferase TylM2 from Streptomyces fradiae to utilise a different amino sugar, tylM2 was integrated into S. erythraea SGT2, and the resulting strain was fed with the 16-membered aglycone tylactone, the normal TylM2 substrate [1].
  • AIMS: To investigate the production of siderophores by Saccharopolyspora erythraea SGT2 and how this production is affected by the inoculum [2].
 

High impact information on SGTB

  • Although rhamnosylerythromycins did not serve directly as substrates for the spinosyn methyltransferases, methylrhamnosyl-erythromycins were obtained by subsequent conversion of the corresponding methylrhamnosyl-erythronolide precursors using the S. erythraea strain SGT2 housing EryCIII, the desosaminyltransferase of the erythromycin pathway [3].
  • The Sgt2 gene was identified by deduced protein sequence homology to the previously identified Sgt1 gene [4].

References

  1. A defined system for hybrid macrolide biosynthesis in Saccharopolyspora erythraea. Gaisser, S., Reather, J., Wirtz, G., Kellenberger, L., Staunton, J., Leadlay, P.F. Mol. Microbiol. (2000) [Pubmed]
  2. Identification of erythrobactin, a hydroxamate-type siderophore produced by Saccharopolyspora erythraea. Oliveira, P.H., Batagov, A., Ward, J., Baganz, F., Krabben, P. Lett. Appl. Microbiol. (2006) [Pubmed]
  3. New erythromycin derivatives from Saccharopolyspora erythraea using sugar O-methyltransferases from the spinosyn biosynthetic gene cluster. Gaisser, S., Lill, R., Wirtz, G., Grolle, F., Staunton, J., Leadlay, P.F. Mol. Microbiol. (2001) [Pubmed]
  4. The primary in vivo steroidal alkaloid glucosyltransferase from potato. McCue, K.F., Allen, P.V., Shepherd, L.V., Blake, A., Whitworth, J., Maccree, M.M., Rockhold, D.R., Stewart, D., Davies, H.V., Belknap, W.R. Phytochemistry (2006) [Pubmed]
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