Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Gene Review:

Dfna5 - deafness, autosomal dominant 5 (human)

Mus musculus

Synonyms: 2310037D07Rik, 4932441K13Rik, Dfna5h, EG14210, Fin15, ...

Van Laer, L. et al.

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Disease relevance of Dfna5h

To test the hearing impairment, frequency-specific Auditory Brainstem Response (ABR) measurements were performed at different ages in two genetic backgrounds (C57Bl/6J and CBA/Ca), but no differences between Dfna5-/- and Dfna5+/+ mice could be demonstrated [1].

High impact information on Dfna5h

Morphological studies demonstrated significant differences in the number of fourth row outer hair cells between Dfna5-/- mice and their wild-type littermates [1].
In contrast to the results obtained in Dfna5-/- zebrafish, we did not observe different UDP-glucose dehydrogenase and hyaluronic acid levels in Dfna5-/- mice when compared to Dfna5+/+ mice [1].

References

Mice lacking Dfna5 show a diverging number of cochlear fourth row outer hair cells. Van Laer, L., Pfister, M., Thys, S., Vrijens, K., Mueller, M., Umans, L., Serneels, L., Van Nassauw, L., Kooy, F., Smith, R.J., Timmermans, J.P., Van Leuven, F., Van Camp, G. Neurobiol. Dis. (2005) [Pubmed]

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