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Gene Review

BTG4  -  B-cell translocation gene 4

Homo sapiens

Synonyms: BTG family member 4, PC3B, Protein BTG4, Protein PC3b
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Disease relevance of BTG4


High impact information on BTG4

  • POU2AF1 is a B-cell-specific transcriptional coactivator, and BTG4 is a member of the BTG family of negative regulators of the cell cycle, making both of them good candidate genes for the pathogenesis of 11q- CLL [1].
  • The BTG4 gene, encoding BTG/TOB family protein, as well as the SIK2 gene, encoding salt-inducible serine/threonine kinase 2, were also located within the 11q23.1 region [2].


  1. Identification of a potential role for POU2AF1 and BTG4 in the deletion of 11q23 in chronic lymphocytic leukemia. Auer, R.L., Starczynski, J., McElwaine, S., Bertoni, F., Newland, A.C., Fegan, C.D., Cotter, F.E. Genes Chromosomes Cancer (2005) [Pubmed]
  2. Identification and characterization of human KIAA1391 and mouse Kiaa1391 genes encoding novel RhoGAP family proteins with RA domain and ANXL repeats. Katoh, M., Katoh, M. Int. J. Oncol. (2003) [Pubmed]
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