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Gene Review

SIK2  -  salt-inducible kinase 2

Homo sapiens

Synonyms: DKFZp434K1115, KIAA0781, LOH11CR1I, QIK, Qin-induced kinase, ...
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High impact information on SNF1LK2


Biological context of SNF1LK2

  • Triggering of the calcium and cAMP second messenger pathways by glucose and gut hormones disrupts TORC2:14-3-3 complexes via complementary effects on TORC2 dephosphorylation; calcium influx increases calcineurin activity, whereas cAMP inhibits SIK2 kinase activity [1].
  • These results strongly suggest that SIK2 may play important role(s) in modulating the insulin-signaling cascade of adipocytes, and thus, may be involved in the development of insulin resistance [4].
  • The SIK2 gene was expressed in 3T3-L1 cells at a very early stage of adipogenesis [4].

Anatomical context of SNF1LK2

  • The cloning of salt-inducible kinase-1 (SIK1) that was specifically expressed in the adrenal glands of high-salt diet-fed rats led to subsequent cloning of adipose-specific SIK2 and rather ubiquitous SIK3 [4].

Regulatory relationships of SNF1LK2


  1. The CREB coactivator TORC2 functions as a calcium- and cAMP-sensitive coincidence detector. Screaton, R.A., Conkright, M.D., Katoh, Y., Best, J.L., Canettieri, G., Jeffries, S., Guzman, E., Niessen, S., Yates, J.R., Takemori, H., Okamoto, M., Montminy, M. Cell (2004) [Pubmed]
  2. Adipose-specific expression, phosphorylation of Ser794 in insulin receptor substrate-1, and activation in diabetic animals of salt-inducible kinase-2. Horike, N., Takemori, H., Katoh, Y., Doi, J., Min, L., Asano, T., Sun, X.J., Yamamoto, H., Kasayama, S., Muraoka, M., Nonaka, Y., Okamoto, M. J. Biol. Chem. (2003) [Pubmed]
  3. Salt-inducible kinase in steroidogenesis and adipogenesis. Okamoto, M., Takemori, H., Katoh, Y. Trends Endocrinol. Metab. (2004) [Pubmed]
  4. Salt-inducible kinase (SIK) isoforms: their involvement in steroidogenesis and adipogenesis. Katoh, Y., Takemori, H., Horike, N., Doi, J., Muraoka, M., Min, L., Okamoto, M. Mol. Cell. Endocrinol. (2004) [Pubmed]
  5. IRS-1 regulation in health and disease. Schmitz-Peiffer, C., Whitehead, J.P. IUBMB Life (2003) [Pubmed]
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