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Gene Review

PXK  -  PX domain containing serine/threonine kinase

Homo sapiens

Synonyms: FLJ20335, MONaKA, Modulator of Na,K-ATPase, PX domain-containing protein kinase-like protein
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High impact information on PXK

  • A full-length cDNA of human PX domain containing serine/threonine kinase gene (PXK) that we termed PXK_v1 had previously been cloned [1].
  • Furthermore, transfection of MONaKA inhibits 86Rb+ uptake via the Na,K-ATPase in intact cells [2].
  • Both splice variants of MONaKA are expressed widely throughout the CNS and peripheral nervous system, with different splice variant expression ratios in neurons and glia [2].


  1. Expression pattern and subcellular localization of five splice isoforms of human PXK. Zou, X., Qiu, G., Chen, C., Wu, M., Hu, Y., Zheng, H., Li, X., Gu, S., Ji, C., Mao, Y. Int. J. Mol. Med. (2005) [Pubmed]
  2. MONaKA, a novel modulator of the plasma membrane Na,K-ATPase. Mao, H., Ferguson, T.S., Cibulsky, S.M., Holmqvist, M., Ding, C., Fei, H., Levitan, I.B. J. Neurosci. (2005) [Pubmed]
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