The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)



Gene Review

FANCI  -  Fanconi anemia, complementation group I

Homo sapiens

Synonyms: FLJ10719, Fanconi anemia group I protein, KIAA1794, Protein FACI
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of FANCI


Enzymatic interactions of FANCI


Co-localisations of FANCI

  • The FANCI foci are colocalized perfectly with FANCD2 and partially with proliferating cell nuclear antigen irrespective of mitomycin C treatment [3].

Other interactions of FANCI


  1. FANCI phosphorylation functions as a molecular switch to turn on the Fanconi anemia pathway. Ishiai, M., Kitao, H., Smogorzewska, A., Tomida, J., Kinomura, A., Uchida, E., Saberi, A., Kinoshita, E., Kinoshita-Kikuta, E., Koike, T., Tashiro, S., Elledge, S.J., Takata, M. Nat. Struct. Mol. Biol. (2008) [Pubmed]
  2. FANCI binds branched DNA and is monoubiquitinated by UBE2T-FANCL. Longerich, S., San Filippo, J., Liu, D., Sung, P. J. Biol. Chem. (2009) [Pubmed]
  3. FANCI protein binds to DNA and interacts with FANCD2 to recognize branched structures. Yuan, F., El Hokayem, J., Zhou, W., Zhang, Y. J. Biol. Chem. (2009) [Pubmed]
  4. Identification of the FANCI protein, a monoubiquitinated FANCD2 paralog required for DNA repair. Smogorzewska, A., Matsuoka, S., Vinciguerra, P., McDonald, E.R., Hurov, K.E., Luo, J., Ballif, B.A., Gygi, S.P., Hofmann, K., D'Andrea, A.D., Elledge, S.J. Cell (2007) [Pubmed]
WikiGenes - Universities