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FANCI  -  Fanconi anemia, complementation group I

Homo sapiens

Synonyms: FLJ10719, Fanconi anemia group I protein, KIAA1794, Protein FACI
 
 
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Disease relevance of FANCI

 

Enzymatic interactions of FANCI

 

Co-localisations of FANCI

  • The FANCI foci are colocalized perfectly with FANCD2 and partially with proliferating cell nuclear antigen irrespective of mitomycin C treatment [3].
 

Other interactions of FANCI

References

  1. FANCI phosphorylation functions as a molecular switch to turn on the Fanconi anemia pathway. Ishiai, M., Kitao, H., Smogorzewska, A., Tomida, J., Kinomura, A., Uchida, E., Saberi, A., Kinoshita, E., Kinoshita-Kikuta, E., Koike, T., Tashiro, S., Elledge, S.J., Takata, M. Nat. Struct. Mol. Biol. (2008) [Pubmed]
  2. FANCI binds branched DNA and is monoubiquitinated by UBE2T-FANCL. Longerich, S., San Filippo, J., Liu, D., Sung, P. J. Biol. Chem. (2009) [Pubmed]
  3. FANCI protein binds to DNA and interacts with FANCD2 to recognize branched structures. Yuan, F., El Hokayem, J., Zhou, W., Zhang, Y. J. Biol. Chem. (2009) [Pubmed]
  4. Identification of the FANCI protein, a monoubiquitinated FANCD2 paralog required for DNA repair. Smogorzewska, A., Matsuoka, S., Vinciguerra, P., McDonald, E.R., Hurov, K.E., Luo, J., Ballif, B.A., Gygi, S.P., Hofmann, K., D'Andrea, A.D., Elledge, S.J. Cell (2007) [Pubmed]
 
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