Gene Review:
FANCL - Fanconi anemia, complementation group L
Homo sapiens
Synonyms:
E3 ubiquitin-protein ligase FANCL, FAAP43, FLJ10335, Fanconi anemia group L protein, Fanconi anemia-associated polypeptide of 43 kDa, ...
- A human ortholog of archaeal DNA repair protein Hef is defective in Fanconi anemia complementation group M. Meetei, A.R., Medhurst, A.L., Ling, C., Xue, Y., Singh, T.R., Bier, P., Steltenpool, J., Stone, S., Dokal, I., Mathew, C.G., Hoatlin, M., Joenje, H., de Winter, J.P., Wang, W. Nat. Genet. (2005)
- Altered Expression of FANCL Confers Mitomycin C Sensitivity in Calu-6 Lung Cancer Cells. Zhang, J., Wang, X., Lin, C.J., Couch, F.J., Fei, P. Cancer Biol. Ther. (2006)
- FANCD2 associated with sporadic breast cancer risk. Barroso, E., Milne, R.L., Fernández, L.P., Zamora, P., Arias, J.I., Benítez, J., Ribas, G. Carcinogenesis (2006)
- A novel ubiquitin ligase is deficient in Fanconi anemia. Meetei, A.R., de Winter, J.P., Medhurst, A.L., Wallisch, M., Waisfisz, Q., van de Vrugt, H.J., Oostra, A.B., Yan, Z., Ling, C., Bishop, C.E., Hoatlin, M.E., Joenje, H., Wang, W. Nat. Genet. (2003)
- UBE2T is the E2 in the Fanconi anemia pathway and undergoes negative autoregulation. Machida, Y.J., Machida, Y., Chen, Y., Gurtan, A.M., Kupfer, G.M., D'Andrea, A.D., Dutta, A. Mol. Cell (2006)
- Evidence for subcomplexes in the Fanconi anemia pathway. Medhurst, A.L., Laghmani, e.l. .H., Steltenpool, J., Ferrer, M., Fontaine, C., de Groot, J., Rooimans, M.A., Scheper, R.J., Meetei, A.R., Wang, W., Joenje, H., de Winter, J.P. Blood (2006)
- Drosophila homologs of FANCD2 and FANCL function in DNA repair. Marek, L.R., Bale, A.E. DNA Repair (Amst.) (2006)
- Mouse GGN1 and GGN3, two germ cell-specific proteins from the single gene Ggn, interact with mouse POG and play a role in spermatogenesis. Lu, B., Bishop, C.E. J. Biol. Chem. (2003)
- FANCL replaces BRCA1 as the likely ubiquitin ligase responsible for FANCD2 monoubiquitination. Meetei, A.R., Yan, Z., Wang, W. Cell Cycle (2004)
- Late onset of spermatogenesis and gain of fertility in POG-deficient mice indicate that POG is not necessary for the proliferation of spermatogonia. Lu, B., Bishop, C.E. Biol. Reprod. (2003)
- The WD40 Repeats of FANCL Are Required for Fanconi Anemia Core Complex Assembly. Gurtan, A.M., Stuckert, P., D'Andrea, A.D. J. Biol. Chem. (2006)
- Monoclonal antibody PHF-9 recognizes phosphorylated serine 404 of tau protein and labels paired helical filaments. Zemlan, F.P., Dean, G.E. J. Neurosci. Res. (1996)