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Gene Review

CHST12  -  carbohydrate (chondroitin 4)...

Homo sapiens

Synonyms: C4S-2, C4ST-2, C4ST2, Carbohydrate sulfotransferase 12, Chondroitin 4-O-sulfotransferase 2, ...
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High impact information on CHST12

  • Northern analysis demonstrated that the transcript for C4ST-1 is predominantly expressed in peripheral leukocytes and hematopoietic tissues while the C4ST-2 transcript is more widely expressed in various tissues [1].
  • Both C4ST-1 and C4ST-2, however, did not form 4, 6-di-O-sulfated N-acetylgalactosamine when chondroitin sulfate C was used as an acceptor [1].

Associations of CHST12 with chemical compounds

  • These results indicate C4ST-1 and C4ST-2 play complementary roles in chondroitin and dermatan sulfate synthesis in different tissues [1].


  1. Molecular cloning and expression of two distinct human chondroitin 4-O-sulfotransferases that belong to the HNK-1 sulfotransferase gene family. Hiraoka, N., Nakagawa, H., Ong, E., Akama, T.O., Fukuda, M.N., Fukuda, M. J. Biol. Chem. (2000) [Pubmed]
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