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PRKACB  -  protein kinase, cAMP-dependent, catalytic,...

Homo sapiens

Synonyms: PKA C-beta, PKACB, PKACb, cAMP-dependent protein kinase catalytic subunit beta
 
 
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High impact information on PRKACB

 

Biological context of PRKACB

  • Of particular interest, PKA-Cbeta facilitated the intramolecular interaction of p73alpha, thereby masking the N-terminal transactivation domain with the C-terminal inhibitory domain [1].
  • Constitutive expression of PKA-Cbeta in Rat1A cells induces their transformation, and c-MYC-induced transformation can be reverted by pharmacological inhibition of PKA, suggesting that up-regulation of PKA is critical for c-MYC-associated tumorigenesis [2].
 

Analytical, diagnostic and therapeutic context of PRKACB

References

  1. Identification of protein kinase A catalytic subunit beta as a novel binding partner of p73 and regulation of p73 function. Hanamoto, T., Ozaki, T., Furuya, K., Hosoda, M., Hayashi, S., Nakanishi, M., Yamamoto, H., Kikuchi, H., Todo, S., Nakagawara, A. J. Biol. Chem. (2005) [Pubmed]
  2. c-MYC activates protein kinase A (PKA) by direct transcriptional activation of the PKA catalytic subunit beta (PKA-Cbeta) gene. Wu, K.J., Mattioli, M., Morse, H.C., Dalla-Favera, R. Oncogene (2002) [Pubmed]
  3. Localization of the IGHG, PRKACB, and TNP2 genes in pigs by in situ hybridization. Gu, F., Chowdhary, B.P., Johansson, M., Andersson, L., Gustavsson, I. Mamm. Genome (1994) [Pubmed]
 
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