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Gene Review

PKIA  -  protein kinase (cAMP-dependent, catalytic)...

Homo sapiens

Synonyms: PKI-alpha, PRKACN1, cAMP-dependent protein kinase inhibitor alpha, cAMP-dependent protein kinase inhibitor, muscle/brain isoform
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High impact information on PKIA

  • Consistent with this, microinjection of PKI alpha antibody into serum-starved cells prevented their subsequent cell cycle progression [1].
  • Nuclear levels of PKI alpha remained high through cell division and decreased again as cells reentered G1 [1].
  • PKI alpha expression appeared low in serum-starved cells and in cells in G1 and increased as cells progressed through S phase [1].
  • In addition, the PKI alpha F10 codon was altered to an alanine codon, and this mutation decreased its ability to inhibit C alpha kinase activity, but did not affect its ability to inhibit C alpha Y235S/F239S [2].
  • Fusions of PKI alpha with GST (70 kDa) or PKI beta 1 with maltose-binding protein (MBP) (50 kDa) remain effective at exporting complexes with C-subunit [3].

Biological context of PKIA


Anatomical context of PKIA

  • However, PKIA was specifically expressed as two transcripts of 3.3 kb and 1.5 kb in heart and skeletal muscle [4].

Other interactions of PKIA

  • Cloning and mapping of human PKIB and PKIG, and comparison of tissue expression patterns of three members of the protein kinase inhibitor family, including PKIA [4].

Analytical, diagnostic and therapeutic context of PKIA

  • Northern-blot analysis of three PKI isoforms, including the PKIA identified previously, revealed significant differences in their expression patterns [4].


  1. The expression and intracellular distribution of the heat-stable protein kinase inhibitor is cell cycle regulated. Wen, W., Taylor, S.S., Meinkoth, J.L. J. Biol. Chem. (1995) [Pubmed]
  2. Evidence for the importance of hydrophobic residues in the interactions between the cAMP-dependent protein kinase catalytic subunit and the protein kinase inhibitors. Baude, E.J., Dignam, S.S., Reimann, E.M., Uhler, M.D. J. Biol. Chem. (1994) [Pubmed]
  3. Heat-stable inhibitors of cAMP-dependent protein kinase carry a nuclear export signal. Wen, W., Harootunian, A.T., Adams, S.R., Feramisco, J., Tsien, R.Y., Meinkoth, J.L., Taylor, S.S. J. Biol. Chem. (1994) [Pubmed]
  4. Cloning and mapping of human PKIB and PKIG, and comparison of tissue expression patterns of three members of the protein kinase inhibitor family, including PKIA. Zheng, L., Yu, L., Tu, Q., Zhang, M., He, H., Chen, W., Gao, J., Yu, J., Wu, Q., Zhao, S. Biochem. J. (2000) [Pubmed]
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