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Gene Review

TSR1  -  TSR1, 20S rRNA accumulation, homolog (S....

Homo sapiens

Synonyms: FLJ10534, KIAA1401, Pre-rRNA-processing protein TSR1 homolog
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High impact information on TSR1

  • By systematic expression analysis of a number of chimeric genes composed of human and rat cDNAs, two strong translational suppression regions were mapped in the human DNA pol beta mRNA; one was named TSR-1, corresponding to CGG encoding arginine (arg) at position 4 and the other, termed TSR-2, is located between codons 153 and 199 [1].
  • It contains six thrombospondin repeat type I (TSR-1 to TSR-6) domains and an N-terminal domain [2].
  • Dye-fills of axons revealed four types of thoracic stretch receptor (TSR): an N-cell type (TSR-1), a differentiated N-cell type (TSR-2), a muscle receptor organ (MRO)-type with a long, single receptor muscle (TSR-3) and an MRO-type with a short, single receptor muscle (TSR-4 to TSR-7) [3].
  • Further truncation (deletion of the TSR-1 domain) of ADAMTS-5 significantly reduced aggrecanase activity, although appreciable GAG (heparin)-binding affinity was maintained [4].
  • Similarly, GAG-binding ability, irrespective of the presence of a TSR-1 domain, does not necessarily empower truncated ADAMTSs with proficient aggrecanase activity [4].


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