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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
MeSH Review


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Disease relevance of Mechanoreceptors


Psychiatry related information on Mechanoreceptors

  • The aim of the present study was to test the hypothesis that afferent mechanoreceptor stimuli from the respiratory muscles contribute to the arousal response to CO2 from both non-rapid-eye-movement (NREM) and rapid-eye-movement (REM) sleep [6].
  • These results indicated that the individuals evaluated in this study with ACL injury and good functional and muscular performance did not have proprioceptive deficits, suggesting that the ligament mechanoreceptors, in some cases, might not contribute relevantly to proprioception [7].

High impact information on Mechanoreceptors

  • In D. melanogaster, a common proneural gene called atonal (ato) functions in the initial process of development of a number of segment-specific organs, including the compound eye, the auditory organ and the stretch receptor, suggesting that these organs share an evolutionary origin [8].
  • Here we show that disrupting the mouse BNC1 gene markedly reduces the sensitivity of a specific component of mechanosensation: low-threshold rapidly adapting mechanoreceptors [9].
  • Stretch receptors had currents that differed from those of P2X3 channels, and had no P2X3 immunoreactivity [10].
  • Using electrophysiology in BDNF-deficient mice, we show here that slowly adapting mechanoreceptors (SAM), but not other types of cutaneous afferents, require BDNF in postnatal life for normal mechanotransduction [11].
  • Specific subtypes of cutaneous mechanoreceptors require neurotrophin-3 following peripheral target innervation [12].

Chemical compound and disease context of Mechanoreceptors


Biological context of Mechanoreceptors


Anatomical context of Mechanoreceptors


Associations of Mechanoreceptors with chemical compounds

  • Because TLESRs are considered to be triggered by activation of gastric mechanoreceptors, and because the gamma-aminobutyric acid type B (GABA(B))-receptor agonist baclofen is known to inhibit transmitter release from mechanosensitive afferents, the effects of baclofen on TLESRs in the dog were assessed [25].
  • The gastric phase can be generated by mechanoreceptors utilizing the cholinergic pathways, whereas the intestinal phase is nutrient-specific, partially atropine-sensitive, and independent of cholecystokinin [26].
  • To determine whether or not the digitalis-induced sympathoinhibition in the heart failure patients was simply due to an inotropic effect (stimulation of inhibitory cardiac mechanoreceptors), we studied the responses of seven additional patients with heart failure before and during administration of dobutamine (3.4 +/- 0.4 micrograms/kg/min) [27].
  • The same experiments were repeated after administration of propranolol (0.15 mg/kg i.v.), which is thought to decrease ventricular mechanoreceptor discharge [28].
  • To abolish the effect of rapidly adapting receptors, we used inhaled bupivacaine aerosol, and to abolish the effect of slowly adapting stretch receptor activity, we used sulfur dioxide insufflation [29].

Gene context of Mechanoreceptors

  • The results are consistent with the model that precursor cells intended to become BDNF-dependent mechanoreceptors instead differentiate into NT-3-dependent proprioceptive neurons [30].
  • Previous studies have shown that BDNF is required for the mechanical sensitivity of slowly adapting (SA) mechanoreceptors but not for the postnatal survival of myelinated cutaneous afferent fibers [31].
  • In contrast, the receptive properties of SA mechanoreceptors were not impaired in animals lacking NT4 [31].
  • Conversely, ectopic expression of ceh-17 in the mechanoreceptors, several of which are known to pioneer their tract, leads to exaggerated longitudinal axonal outgrowth [32].
  • This suggests that PECAM-1 may not function as a major mechanoreceptor for activation of MAPK and AKT in ECs and that there are likely to be other mechanoreceptors in ECs functioning to detect shear stress and trigger intercellular signals [33].

Analytical, diagnostic and therapeutic context of Mechanoreceptors


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  11. A role for BDNF in mechanosensation. Carroll, P., Lewin, G.R., Koltzenburg, M., Toyka, K.V., Thoenen, H. Nat. Neurosci. (1998) [Pubmed]
  12. Specific subtypes of cutaneous mechanoreceptors require neurotrophin-3 following peripheral target innervation. Airaksinen, M.S., Koltzenburg, M., Lewin, G.R., Masu, Y., Helbig, C., Wolf, E., Brem, G., Toyka, K.V., Thoenen, H., Meyer, M. Neuron (1996) [Pubmed]
  13. Monosynaptic connexions between wing stretch receptors and flight motoneurones of the locust. Burrows, M. J. Exp. Biol. (1975) [Pubmed]
  14. Receptive fields and properties of a new cluster of mechanoreceptor neurons innervating the mantle region and the branchial cavity of the marine mollusk Aplysia californica. Dubuc, B., Castellucci, V.F. J. Exp. Biol. (1991) [Pubmed]
  15. A study of mechanoreceptors in fibrocartilage masses in the defect of pars interarticularis. Hasegawa, S., Yamamoto, H., Morisawa, Y., Michinaka, Y. Journal of orthopaedic science : official journal of the Japanese Orthopaedic Association. (1999) [Pubmed]
  16. Genetic dissection of mechanosensory transduction: mechanoreception-defective mutations of Drosophila. Kernan, M., Cowan, D., Zuker, C. Neuron (1994) [Pubmed]
  17. Sequential cytoplasmic calcium signals in a 2-stage platelet activation process induced by the glycoprotein Ibalpha mechanoreceptor. Mazzucato, M., Pradella, P., Cozzi, M.R., De Marco, L., Ruggeri, Z.M. Blood (2002) [Pubmed]
  18. Effects of aerosol-applied capsaicin, histamine and prostaglandin E2 on airway sensory receptors of anaesthetized cats. Mohammed, S.P., Higenbottam, T.W., Adcock, J.J. J. Physiol. (Lond.) (1993) [Pubmed]
  19. Pentobarbitone interference with inhibitory synaptic transmission in crayfish stretch receptor neurones. Aickin, C.C., Deisz, R.A. J. Physiol. (Lond.) (1981) [Pubmed]
  20. The effects of 5-HT on articular sensory receptors in normal and arthritic rats. Birrell, G.J., McQueen, D.S., Iggo, A., Grubb, B.D. Br. J. Pharmacol. (1990) [Pubmed]
  21. Single neuron mosaics of the drosophila gigas mutant project beyond normal targets and modify behavior. Canal, I., Acebes, A., Ferrús, A. J. Neurosci. (1998) [Pubmed]
  22. Glial growth factor rescues Schwann cells of mechanoreceptors from denervation-induced apoptosis. Kopp, D.M., Trachtenberg, J.T., Thompson, W.J. J. Neurosci. (1997) [Pubmed]
  23. Roles of capsaicin-insensitive nociceptors in cutaneous pain and secondary hyperalgesia. Magerl, W., Fuchs, P.N., Meyer, R.A., Treede, R.D. Brain (2001) [Pubmed]
  24. Renal sensory receptor activation by calcitonin gene-related peptide. Gontijo, J.R., Kopp, U.C. Hypertension (1994) [Pubmed]
  25. Activation of the GABA(B) receptor inhibits transient lower esophageal sphincter relaxations in dogs. Lehmann, A., Antonsson, M., Bremner-Danielsen, M., Flärdh, M., Hansson-Brändén, L., Kärrberg, L. Gastroenterology (1999) [Pubmed]
  26. Participation of gastric mechanoreceptors and intestinal chemoreceptors in the gastrocolonic response. Wiley, J., Tatum, D., Keinath, R., Chung, O.Y. Gastroenterology (1988) [Pubmed]
  27. Sympathoinhibitory responses to digitalis glycosides in heart failure patients. Direct evidence from sympathetic neural recordings. Ferguson, D.W., Berg, W.J., Sanders, J.S., Roach, P.J., Kempf, J.S., Kienzle, M.G. Circulation (1989) [Pubmed]
  28. Contrasting effects of propranolol on sympathetic nerve activity and vascular resistance during orthostatic stress. Jacobsen, T.N., Converse, R.L., Victor, R.G. Circulation (1992) [Pubmed]
  29. Contribution of pulmonary receptors to the heart rate response to acute hypoxemia in rabbits. Kato, H., Menon, A.S., Chen, F.J., Slutsky, A.S. Circulation (1988) [Pubmed]
  30. Loss of brain-derived neurotrophic factor-dependent neural crest-derived sensory neurons in neurotrophin-4 mutant mice. Liebl, D.J., Klesse, L.J., Tessarollo, L., Wohlman, T., Parada, L.F. Proc. Natl. Acad. Sci. U.S.A. (2000) [Pubmed]
  31. Neurotrophin 4 is required for the survival of a subclass of hair follicle receptors. Stucky, C.L., DeChiara, T., Lindsay, R.M., Yancopoulos, G.D., Koltzenburg, M. J. Neurosci. (1998) [Pubmed]
  32. The homeodomain protein CePHOX2/CEH-17 controls antero-posterior axonal growth in C. elegans. Pujol, N., Torregrossa, P., Ewbank, J.J., Brunet, J.F. Development (2000) [Pubmed]
  33. MAPKs (ERK1/2, p38) and AKT can be phosphorylated by shear stress independently of platelet endothelial cell adhesion molecule-1 (CD31) in vascular endothelial cells. Sumpio, B.E., Yun, S., Cordova, A.C., Haga, M., Zhang, J., Koh, Y., Madri, J.A. J. Biol. Chem. (2005) [Pubmed]
  34. Effect of intrarenal bradykinin infusion on vasopressin release in rabbits. Yamamoto, A., Keil, L.C., Reid, I.A. Hypertension (1992) [Pubmed]
  35. Distribution and behaviour of glabrous cutaneous receptors in the human foot sole. Kennedy, P.M., Inglis, J.T. J. Physiol. (Lond.) (2002) [Pubmed]
  36. Cutaneous injection of the capsaicin analogue, NE-21610, produces analgesia to heat but not to mechanical stimuli in man. Davis, K.D., Meyer, R.A., Turnquist, J.L., Filloon, T.G., Pappagallo, M., Campbell, J.N. Pain (1995) [Pubmed]
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