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Gene Review

ADAMTS5  -  ADAM metallopeptidase with thrombospondin...

Homo sapiens

Synonyms: A disintegrin and metalloproteinase with thrombospondin motifs 11, A disintegrin and metalloproteinase with thrombospondin motifs 5, ADAM-TS 11, ADAM-TS 5, ADAM-TS5, ...
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Disease relevance of ADAMTS5


High impact information on ADAMTS5

  • Finally, the third group comprises genes that are expressed in cells of endothelial tissue and cartilage including E-selectin, fibronectin-1, matrix Gla protein, and aggrecanase-2 [5].
  • Here we show that despite ablation of ADAMTS-5 activity, aggrecanolysis can still occur at two preferred sites in the chondroitin sulfate-rich region [6].
  • ADAMTS-5, but not ADAMTS-1, -4, or -9, was up-regulated 8-fold by retinoic acid and 17-fold by IL-1alpha treatment [6].
  • ADAMTS-5 Deficiency Does Not Block Aggrecanolysis at Preferred Cleavage Sites in the Chondroitin Sulfate-rich Region of Aggrecan [6].
  • RESULTS: ADAMTS-4, but not ADAMTS-5, was induced in human chondrocytes infected with B burgdorferi [7].

Biological context of ADAMTS5


Anatomical context of ADAMTS5


Associations of ADAMTS5 with chemical compounds


Enzymatic interactions of ADAMTS5


Regulatory relationships of ADAMTS5


Other interactions of ADAMTS5

  • Furthermore, OA, RA, and nonarthritis ST contained similar amounts of immunoreactive aggrecanase-2 [20].
  • Finally, the zymogen of stromelysin (MMP-3) was not activated by either ADAM-TS4 or ADAM-TS5 [9].
  • The possibility that synovium-derived ADAMTS-5 may play a role in cartilage aggrecan breakdown is discussed [13].
  • Further truncation (deletion of the TSR-1 domain) of ADAMTS-5 significantly reduced aggrecanase activity, although appreciable GAG (heparin)-binding affinity was maintained [18].
  • In vitro, glioblastoma-derived ADAMTS5 degrades recombinant human brevican to several smaller fragments [1].

Analytical, diagnostic and therapeutic context of ADAMTS5


  1. Matrix-degrading proteases ADAMTS4 and ADAMTS5 (disintegrins and metalloproteinases with thrombospondin motifs 4 and 5) are expressed in human glioblastomas. Held-Feindt, J., Paredes, E.B., Blömer, U., Seidenbecher, C., Stark, A.M., Mehdorn, H.M., Mentlein, R. Int. J. Cancer (2006) [Pubmed]
  2. Deletion of active ADAMTS5 prevents cartilage degradation in a murine model of osteoarthritis. Glasson, S.S., Askew, R., Sheppard, B., Carito, B., Blanchet, T., Ma, H.L., Flannery, C.R., Peluso, D., Kanki, K., Yang, Z., Majumdar, M.K., Morris, E.A. Nature (2005) [Pubmed]
  3. Human glioblastomas overexpress ADAMTS-5 that degrades brevican. Nakada, M., Miyamori, H., Kita, D., Takahashi, T., Yamashita, J., Sato, H., Miura, R., Yamaguchi, Y., Okada, Y. Acta Neuropathol. (2005) [Pubmed]
  4. Metalloproteinase ADAMTS-1 but not ADAMTS-5 is manifold overexpressed in neurodegenerative disorders as Down syndrome, Alzheimer's and Pick's disease. Miguel, R.F., Pollak, A., Lubec, G. Brain Res. Mol. Brain Res. (2005) [Pubmed]
  5. Alteration in the gene expression pattern of primary monocytes after adhesion to endothelial cells. Thomas-Ecker, S., Lindecke, A., Hatzmann, W., Kaltschmidt, C., Zänker, K.S., Dittmar, T. Proc. Natl. Acad. Sci. U.S.A. (2007) [Pubmed]
  6. ADAMTS-5 Deficiency Does Not Block Aggrecanolysis at Preferred Cleavage Sites in the Chondroitin Sulfate-rich Region of Aggrecan. East, C.J., Stanton, H., Golub, S.B., Rogerson, F.M., Fosang, A.J. J. Biol. Chem. (2007) [Pubmed]
  7. Role of aggrecanase 1 in Lyme arthritis. Behera, A.K., Hildebrand, E., Szafranski, J., Hung, H.H., Grodzinsky, A.J., Lafyatis, R., Koch, A.E., Kalish, R., Perides, G., Steere, A.C., Hu, L.T. Arthritis Rheum. (2006) [Pubmed]
  8. ADAM-TS5, ADAM-TS6, and ADAM-TS7, novel members of a new family of zinc metalloproteases. General features and genomic distribution of the ADAM-TS family. Hurskainen, T.L., Hirohata, S., Seldin, M.F., Apte, S.S. J. Biol. Chem. (1999) [Pubmed]
  9. Characterization of human aggrecanase 2 (ADAM-TS5): substrate specificity studies and comparison with aggrecanase 1 (ADAM-TS4). Tortorella, M.D., Liu, R.Q., Burn, T., Newton, R.C., Arner, E. Matrix Biol. (2002) [Pubmed]
  10. Licofelone reduces progression of structural changes in a canine model of osteoarthritis under curative conditions: effect on protease expression and activity. Moreau, M., Boileau, C., Martel-Pelletier, J., Brunet, J., Laufer, S., Pelletier, J.P. J. Rheumatol. (2006) [Pubmed]
  11. High molecular weight hyaluronic acid down-regulates the gene expression of osteoarthritis-associated cytokines and enzymes in fibroblast-like synoviocytes from patients with early osteoarthritis. Wang, C.T., Lin, Y.T., Chiang, B.L., Lin, Y.H., Hou, S.M. Osteoarthr. Cartil. (2006) [Pubmed]
  12. Animal models of osteoarthritis: lessons learned while seeking the 'Holy Grail'. Ameye, L.G., Young, M.F. Current opinion in rheumatology. (2006) [Pubmed]
  13. Expression and activity of ADAMTS-5 in synovium. Vankemmelbeke, M.N., Holen, I., Wilson, A.G., Ilic, M.Z., Handley, C.J., Kelner, G.S., Clark, M., Liu, C., Maki, R.A., Burnett, D., Buttle, D.J. Eur. J. Biochem. (2001) [Pubmed]
  14. ADAMTS5-mediated aggrecanolysis in murine epiphyseal chondrocyte cultures. Stewart, M.C., Fosang, A.J., Bai, Y., Osborn, B., Plaas, A., Sandy, J.D. Osteoarthr. Cartil. (2006) [Pubmed]
  15. Release of hyaluronan and hyaladherins (aggrecan G1 domain and link proteins) from articular cartilage exposed to ADAMTS-4 (aggrecanase 1) or ADAMTS-5 (aggrecanase 2). Chockalingam, P.S., Zeng, W., Morris, E.A., Flannery, C.R. Arthritis Rheum. (2004) [Pubmed]
  16. Expression of ADAMTS-5/implantin in human decidual stromal cells: regulatory effects of cytokines. Zhu, H., Leung, P.C., Maccalman, C.D. Hum. Reprod. (2007) [Pubmed]
  17. Cloning and characterization of ADAMTS11, an aggrecanase from the ADAMTS family. Abbaszade, I., Liu, R.Q., Yang, F., Rosenfeld, S.A., Ross, O.H., Link, J.R., Ellis, D.M., Tortorella, M.D., Pratta, M.A., Hollis, J.M., Wynn, R., Duke, J.L., George, H.J., Hillman, M.C., Murphy, K., Wiswall, B.H., Copeland, R.A., Decicco, C.P., Bruckner, R., Nagase, H., Itoh, Y., Newton, R.C., Magolda, R.L., Trzaskos, J.M., Burn, T.C. J. Biol. Chem. (1999) [Pubmed]
  18. Glycosaminoglycan-binding properties and aggrecanase activities of truncated ADAMTSs: comparative analyses with ADAMTS-5, -9, -16 and -18. Zeng, W., Corcoran, C., Collins-Racie, L.A., Lavallie, E.R., Morris, E.A., Flannery, C.R. Biochim. Biophys. Acta (2006) [Pubmed]
  19. The cleavage of biglycan by aggrecanases. Melching, L.I., Fisher, W.D., Lee, E.R., Mort, J.S., Roughley, P.J. Osteoarthr. Cartil. (2006) [Pubmed]
  20. Expression and regulation of aggrecanase in arthritis: the role of TGF-beta. Yamanishi, Y., Boyle, D.L., Clark, M., Maki, R.A., Tortorella, M.D., Arner, E.C., Firestein, G.S. J. Immunol. (2002) [Pubmed]
  21. Implication of interleukin 18 in production of matrix metalloproteinases in articular chondrocytes in arthritis: direct effect on chondrocytes may not be pivotal. Dai, S.M., Shan, Z.Z., Nishioka, K., Yudoh, K. Ann. Rheum. Dis. (2005) [Pubmed]
  22. Collagen and aggrecan degradation is blocked in interleukin-1-treated cartilage explants by an inhibitor of IkappaB kinase through suppression of metalloproteinase expression. Pattoli, M.A., MacMaster, J.F., Gregor, K.R., Burke, J.R. J. Pharmacol. Exp. Ther. (2005) [Pubmed]
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