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Gene Review

PRKCZ  -  protein kinase C, zeta

Homo sapiens

Synonyms: PKC-ZETA, PKC2, Protein kinase C zeta type, nPKC-zeta
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High impact information on PRKCZ

  • Protein kinase C (PKC) assays and immunoblot analysis of calcium-dependent (cPKC) and calcium-independent (nPKC) isoforms revealed that nPKC-epsilon was strikingly absent in the mutant, which otherwise expressed in comparable amounts all other isotypes (cPKC-alpha, cPKC-beta, and nPKC-zeta) also present in the wild type [1].
  • The GABRD gene maps immediately proximal to the PRKCZ gene that is located between marker D1S243 and cosmid D1Z2--a region thought to be critical for cognition and speech development [2].
  • Two major substrates for human erythrocyte protein kinase C (PK-C) of Mr 120,000 and 110,000, previously named PKC-1 and PKC-2 [Palfrey, H. C. & Waseem, A. (1985) J. Biol. Chem. 260, 16021-16029] have been found to be identical to CaM-BP 103/97 or 'adducin', recently described by K [3].
  • Furthermore, haplotypes at five SNP sites of PRKCZ gene were identified [4].
  • Allele frequency of one SNP, rs436045 in the protein kinase C/zetagene (PRKCZ) was statistically different between the case and control groups(P<0.05) [4].

Biological context of PRKCZ

  • Molecular simulation of the P2X3 receptor structure indicated no overlap between assumed nucleotide binding domains and the relevant phosphorylation sites PKC2 and PKC3. alpha,beta-meATP-induced currents through native homomeric P2X3 receptors of rat dorsal root ganglia were also facilitated by UTP [5].


  1. Human leukemia K562 cell mutant (K562/OA200) selected for resistance to okadaic acid (protein phosphatase inhibitor) lacks protein kinase C-epsilon, exhibits multidrug resistance phenotype, and expresses drug pump P-glycoprotein. Zheng, B., Chambers, T.C., Raynor, R.L., Markham, P.N., Gebel, H.M., Vogler, W.R., Kuo, J.F. J. Biol. Chem. (1994) [Pubmed]
  2. The human gamma-aminobutyric acid A receptor delta (GABRD) gene: molecular characterisation and tissue-specific expression. Windpassinger, C., Kroisel, P.M., Wagner, K., Petek, E. Gene (2002) [Pubmed]
  3. Erythrocyte adducin. Comparison of the alpha- and beta-subunits and multiple-site phosphorylation by protein kinase C and cAMP-dependent protein kinase. Waseem, A., Palfrey, H.C. Eur. J. Biochem. (1988) [Pubmed]
  4. Protein kinase C/zeta (PRKCZ) gene is associated with type 2 diabetes in Han population of North China and analysis of its haplotypes. Li, Y.F., Sun, H.X., Wu, G.D., Du, W.N., Zuo, J., Shen, Y., Qiang, B.Q., Yao, Z.J., Wang, H., Huang, W., Chen, Z., Xiong, M.M., Meng, Y., Fang, F.D. World J. Gastroenterol. (2003) [Pubmed]
  5. Regulation of human recombinant P2X3 receptors by ecto-protein kinase C. Wirkner, K., Stanchev, D., Köles, L., Klebingat, M., Dihazi, H., Flehmig, G., Vial, C., Evans, R.J., Fürst, S., Mager, P.P., Eschrich, K., Illes, P. J. Neurosci. (2005) [Pubmed]
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