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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
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Disease relevance of Ganglia


Psychiatry related information on Ganglia


High impact information on Ganglia

  • Here we show that Cited2-/- embryos die with cardiac malformations, adrenal agenesis, abnormal cranial ganglia and exencephaly [10].
  • Here we report that mice homozygous for a targeted null mutation at the CrkL locus (gene symbol Crkol for mice) exhibit defects in multiple cranial and cardiac neural crest derivatives including the cranial ganglia, aortic arch arteries, cardiac outflow tract, thymus, parathyroid glands and craniofacial structures [11].
  • We describe cloning of a candidate dt gene, dystonin, that is predominantly expressed in the dorsal root ganglia and other sites of neurodegeneration in dt mice [12].
  • The brain and spinal cord of the mutants appear normal, but their olfactory epithelium and sympathetic, parasympathetic, and enteric ganglia are severely affected [13].
  • Cleavage of NgR and other GPI-linked proteins from the cell surface renders axons of dorsal root ganglia insensitive to OMgp [14].

Chemical compound and disease context of Ganglia


Biological context of Ganglia


Anatomical context of Ganglia


Associations of Ganglia with chemical compounds

  • Synthesis of substance P is reduced by some 90% in ganglia from rats treated neonatally with capsaicin, a drug which is thought to destroy a population of primary afferent neurones [30].
  • These receptors do not bind alpha-bungarotoxin but have a high affinity for nicotine and antibodies raised against them block the function of acetylcholine receptors in ciliary ganglia [31].
  • We report here that E/C8-positive mesenchymal cells of the arches can develop into neurones spontaneously in culture, or can migrate into aneural guts with which they are co-cultured and form enteric ganglia [32].
  • At a dose of 1.8 to 10 nanomoles, the peptide enhanced and prolonged the postganglionic discharge elicited by acetyl-beta-methylcholine, enhanced muscarinic transmission in ganglia treated with an anticholinesterase agent, and enhanced the late muscarinic discharge elicited by acetylcholine [33].
  • Prediction of immediate and future rewards differentially recruits cortico-basal ganglia loops [34].

Gene context of Ganglia


Analytical, diagnostic and therapeutic context of Ganglia


  1. Sox10 mutation disrupts neural crest development in Dom Hirschsprung mouse model. Southard-Smith, E.M., Kos, L., Pavan, W.J. Nat. Genet. (1998) [Pubmed]
  2. Pax3 is required for enteric ganglia formation and functions with Sox10 to modulate expression of c-ret. Lang, D., Chen, F., Milewski, R., Li, J., Lu, M.M., Epstein, J.A. J. Clin. Invest. (2000) [Pubmed]
  3. Differential contributions of Ng-CAM and N-CAM to cell adhesion in different neural regions. Hoffman, S., Friedlander, D.R., Chuong, C.M., Grumet, M., Edelman, G.M. J. Cell Biol. (1986) [Pubmed]
  4. Increased substance P responses in dorsal root ganglia and intestinal macrophages during Clostridium difficile toxin A enteritis in rats. Castagliuolo, I., Keates, A.C., Qiu, B., Kelly, C.P., Nikulasson, S., Leeman, S.E., Pothoulakis, C. Proc. Natl. Acad. Sci. U.S.A. (1997) [Pubmed]
  5. Mechanisms of embryonal tumor initiation: distinct roles for MycN expression and MYCN amplification. Hansford, L.M., Thomas, W.D., Keating, J.M., Burkhart, C.A., Peaston, A.E., Norris, M.D., Haber, M., Armati, P.J., Weiss, W.A., Marshall, G.M. Proc. Natl. Acad. Sci. U.S.A. (2004) [Pubmed]
  6. Visual attention in Huntington's disease: the effect of cueing on saccade latencies and manual reaction times. Tsai, T.T., Lasker, A., Zee, D.S. Neuropsychologia. (1995) [Pubmed]
  7. Participation of GABA in establishing behavioral hierarchies in the terrestrial snail. Bravarenko, N.I., Ierusalimsky, V.N., Korshunova, T.A., Malyshev, A.Y., Zakharov, I.S., Balaban, P.M. Experimental brain research. Experimentelle Hirnforschung. Expérimentation cérébrale. (2001) [Pubmed]
  8. Adult-onset tic disorder, motor stereotypies, and behavioural disturbance associated with antibasal ganglia antibodies. Edwards, M.J., Dale, R.C., Church, A.J., Trikouli, E., Quinn, N.P., Lees, A.J., Giovannoni, G., Bhatia, K.P. Mov. Disord. (2004) [Pubmed]
  9. Pyridoxine (vitamin B6) neurotoxicity: enhancement by protein-deficient diet. Levine, S., Saltzman, A. Journal of applied toxicology : JAT. (2004) [Pubmed]
  10. Cardiac malformations, adrenal agenesis, neural crest defects and exencephaly in mice lacking Cited2, a new Tfap2 co-activator. Bamforth, S.D., Bragança, J., Eloranta, J.J., Murdoch, J.N., Marques, F.I., Kranc, K.R., Farza, H., Henderson, D.J., Hurst, H.C., Bhattacharya, S. Nat. Genet. (2001) [Pubmed]
  11. Mice lacking the homologue of the human 22q11.2 gene CRKL phenocopy neurocristopathies of DiGeorge syndrome. Guris, D.L., Fantes, J., Tara, D., Druker, B.J., Imamoto, A. Nat. Genet. (2001) [Pubmed]
  12. The mouse dystonia musculorum gene is a neural isoform of bullous pemphigoid antigen 1. Brown, A., Bernier, G., Mathieu, M., Rossant, J., Kothary, R. Nat. Genet. (1995) [Pubmed]
  13. Mammalian achaete-scute homolog 1 is required for the early development of olfactory and autonomic neurons. Guillemot, F., Lo, L.C., Johnson, J.E., Auerbach, A., Anderson, D.J., Joyner, A.L. Cell (1993) [Pubmed]
  14. Oligodendrocyte-myelin glycoprotein is a Nogo receptor ligand that inhibits neurite outgrowth. Wang, K.C., Koprivica, V., Kim, J.A., Sivasankaran, R., Guo, Y., Neve, R.L., He, Z. Nature (2002) [Pubmed]
  15. Role of peptidergic neurons in ocular herpes simplex infection in mice. Herbort, C.P., Weissman, S.S., Payan, D.G. FASEB J. (1989) [Pubmed]
  16. Insulin-like growth factor I prevents mannitol-induced degradation of focal adhesion kinase and Akt. Kim, B., Feldman, E.L. J. Biol. Chem. (2002) [Pubmed]
  17. Synergistic action of advanced glycation end products and endogenous nitric oxide leads to neuronal apoptosis in vitro: a new insight into selective nitrergic neuropathy in diabetes. Cellek, S., Qu, W., Schmidt, A.M., Moncada, S. Diabetologia (2004) [Pubmed]
  18. Quantitation of latent varicella-zoster virus and herpes simplex virus genomes in human trigeminal ganglia. Pevenstein, S.R., Williams, R.K., McChesney, D., Mont, E.K., Smialek, J.E., Straus, S.E. J. Virol. (1999) [Pubmed]
  19. Trigeminal ganglion infection by thymidine kinase-negative mutants of herpes simplex virus after in vivo complementation. Tenser, R.B., Edris, W.A. J. Virol. (1987) [Pubmed]
  20. Evidence that substance P is a neurotransmitter in the myenteric plexus. Morita, K., North, R.A., Katayama, Y. Nature (1980) [Pubmed]
  21. Effects of putative neurotransmitters on sympathetic preganglionic neurons. McCall, R.B. Annu. Rev. Physiol. (1988) [Pubmed]
  22. Clinical, biochemical and molecular genetic correlations in Friedreich's ataxia. Bradley, J.L., Blake, J.C., Chamberlain, S., Thomas, P.K., Cooper, J.M., Schapira, A.H. Hum. Mol. Genet. (2000) [Pubmed]
  23. Comparison of innervation and agrin-induced tyrosine phosphorylation of the nicotinic acetylcholine receptor. Qu, Z., Huganir, R.L. J. Neurosci. (1994) [Pubmed]
  24. Involvement of leukemia inhibitory factor and nerve growth factor in the development of dorsal root ganglion neurons. Murphy, M., Reid, K., Brown, M.A., Bartlett, P.F. Development (1993) [Pubmed]
  25. Specification of the mammalian cochlea is dependent on Sonic hedgehog. Riccomagno, M.M., Martinu, L., Mulheisen, M., Wu, D.K., Epstein, D.J. Genes Dev. (2002) [Pubmed]
  26. Mesp2: a novel mouse gene expressed in the presegmented mesoderm and essential for segmentation initiation. Saga, Y., Hata, N., Koseki, H., Taketo, M.M. Genes Dev. (1997) [Pubmed]
  27. Selective modulation of desensitization at AMPA versus kainate receptors by cyclothiazide and concanavalin A. Partin, K.M., Patneau, D.K., Winters, C.A., Mayer, M.L., Buonanno, A. Neuron (1993) [Pubmed]
  28. Substance P-containing nerve fibers are numerous in human but not in feline intestinal mucosa. Brodin, E., Sjölund, K., Håkanson, R., Sundler, F. Gastroenterology (1983) [Pubmed]
  29. Migration of the myoelectric complex after interruption of the myenteric plexus: intestinal transection and regeneration of enteric nerves in the guinea pig. Galligan, J.J., Furness, J.B., Costa, M. Gastroenterology (1989) [Pubmed]
  30. Cycloheximide-sensitive synthesis of substance P by isolated dorsal root ganglia. Harmar, A., Schofield, J.G., Keen, P. Nature (1980) [Pubmed]
  31. Functional acetylcholine receptor in PC12 cells reacts with a monoclonal antibody to brain nicotinic receptors. Whiting, P.J., Schoepfer, R., Swanson, L.W., Simmons, D.M., Lindstrom, J.M. Nature (1987) [Pubmed]
  32. Enteric neurogenesis by neural crest-derived branchial arch mesenchymal cells. Ciment, G., Weston, J.A. Nature (1983) [Pubmed]
  33. Depolarization and muscarinic excitation induced in a sympathetic ganglion by vasoactive intestinal polypeptide. Kawatani, M., Rutigliano, M., de Groat, W.C. Science (1985) [Pubmed]
  34. Prediction of immediate and future rewards differentially recruits cortico-basal ganglia loops. Tanaka, S.C., Doya, K., Okada, G., Ueda, K., Okamoto, Y., Yamawaki, S. Nat. Neurosci. (2004) [Pubmed]
  35. Differential activities of the RET tyrosine kinase receptor isoforms during mammalian embryogenesis. de Graaff, E., Srinivas, S., Kilkenny, C., D'Agati, V., Mankoo, B.S., Costantini, F., Pachnis, V. Genes Dev. (2001) [Pubmed]
  36. Sensory fibres expressing capsaicin receptor TRPV1 in patients with rectal hypersensitivity and faecal urgency. Chan, C.L., Facer, P., Davis, J.B., Smith, G.D., Egerton, J., Bountra, C., Williams, N.S., Anand, P. Lancet (2003) [Pubmed]
  37. Anandamide acts as an intracellular messenger amplifying Ca2+ influx via TRPV1 channels. van der Stelt, M., Trevisani, M., Vellani, V., De Petrocellis, L., Schiano Moriello, A., Campi, B., McNaughton, P., Geppetti, P., Di Marzo, V. EMBO J. (2005) [Pubmed]
  38. The intermediate filament protein peripherin is the specific interaction partner of mouse BPAG1-n (dystonin) in neurons. Leung, C.L., Sun, D., Liem, R.K. J. Cell Biol. (1999) [Pubmed]
  39. An antagonist-insensitive P2X receptor expressed in epithelia and brain. Buell, G., Lewis, C., Collo, G., North, R.A., Surprenant, A. EMBO J. (1996) [Pubmed]
  40. Reactivated and latent varicella-zoster virus in human dorsal root ganglia. Lungu, O., Annunziato, P.W., Gershon, A., Staugaitis, S.M., Josefson, D., LaRussa, P., Silverstein, S.J. Proc. Natl. Acad. Sci. U.S.A. (1995) [Pubmed]
  41. A proinflammatory chemokine, CCL3, sensitizes the heat- and capsaicin-gated ion channel TRPV1. Zhang, N., Inan, S., Inan, S., Cowan, A., Sun, R., Wang, J.M., Rogers, T.J., Caterina, M., Oppenheim, J.J. Proc. Natl. Acad. Sci. U.S.A. (2005) [Pubmed]
  42. Isolation, sequence analysis, and physiological properties of enkephalins in the nervous tissue of the shore crab Carcinus maenas L. Lüschen, W., Buck, F., Willig, A., Jaros, P.P. Proc. Natl. Acad. Sci. U.S.A. (1991) [Pubmed]
  43. Effects of sodium pentobarbital anesthesia and neurotrophic factor on the maintenance of acetylcholinesterase and butyrylcholinesterase in the preganglionically denervated superior cervical ganglion of the cat. Koelle, G.B., Ruch, G.A., Uchida, E. Proc. Natl. Acad. Sci. U.S.A. (1983) [Pubmed]
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