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Gene Review:

APOBR - apolipoprotein B receptor

Homo sapiens

Synonyms: APOB100R, APOB48R, Apolipoprotein B receptor, Apolipoprotein B-100 receptor, Apolipoprotein B-48 receptor, ...

Kawakami, A. et al., Haraguchi, G. et al., Fujita, Y. et al., Palmer, A.M. et al., Kawakami, A. et al.

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Disease relevance of APOB48R

Our results indicate that variations in APOB48R and nearby genes are among the many factors involved in hypercholesterolemia [1].

High impact information on APOB48R

Certain triglyceride-rich lipoproteins (TRLs), specifically chylomicrons, dyslipemic VLDLs, and their remnants, are atherogenic and can induce monocyte-macrophage foam cell formation in vitro via the apolipoprotein B-48 receptor (apoB-48R) [2].
Expression of LDL receptor related protein (LRP) and apolipoprotein B48 receptor (apoB48R) was also examined in both differentiating monocytes, and monocyte-derived macrophages, incubated with TRL [3].
Association of nucleotide variations in the apolipoprotein B48 receptor gene (APOB48R) with hypercholesterolemia [1].
We examined the involvement of apoB48 receptor (apoB48R), a novel receptor for RLPs, in that process in vitro and its potential regulation by pitavastatin [4].
More recently, we reported that apoB48 receptor was involved in RLP-induced foam cell formation in macrophages [5].

Anatomical context of APOB48R

Pitavastatin inhibits remnant lipoprotein-induced macrophage foam cell formation through ApoB48 receptor-dependent mechanism [4].

References

Association of nucleotide variations in the apolipoprotein B48 receptor gene (APOB48R) with hypercholesterolemia. Fujita, Y., Ezura, Y., Bujo, H., Nakajima, T., Takahashi, K., Kamimura, K., Iino, Y., Katayama, Y., Saito, Y., Emi, M. J. Hum. Genet. (2005) [Pubmed]
PPAR(alpha) and PPAR(gamma) activators suppress the monocyte-macrophage apoB-48 receptor. Haraguchi, G., Kobayashi, Y., Brown, M.L., Tanaka, A., Isobe, M., Gianturco, S.H., Bradley, W.A. J. Lipid Res. (2003) [Pubmed]
Differential uptake of subfractions of triglyceride-rich lipoproteins by THP-1 macrophages. Palmer, A.M., Nova, E., Anil, E., Jackson, K., Bateman, P., Wolstencroft, E., Williams, C.M., Yaqoob, P. Atherosclerosis (2005) [Pubmed]
Pitavastatin inhibits remnant lipoprotein-induced macrophage foam cell formation through ApoB48 receptor-dependent mechanism. Kawakami, A., Tani, M., Chiba, T., Yui, K., Shinozaki, S., Nakajima, K., Tanaka, A., Shimokado, K., Yoshida, M. Arterioscler. Thromb. Vasc. Biol. (2005) [Pubmed]
Remnant lipoproteins and atherogenesis. Kawakami, A., Yoshida, M. J. Atheroscler. Thromb. (2005) [Pubmed]

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APOBR	Bos taurus
APOBR	Canis lupus familiaris
APOBR	Macaca mulatta
Apobr	Mus musculus
LOC743592	Pan troglodytes
Apobr	Rattus norvegicus

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