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Gene Review

Stk3  -  serine/threonine kinase 3

Mus musculus

Synonyms: 0610042I06Rik, MST, MST-2, Mammalian STE20-like protein kinase 2, Mess1, ...
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High impact information on Stk3

  • In apoptotic cells, the activation of MST does not require phosphorylation in the activation loop and occurs through the release of C-terminal regulatory domain by caspase-dependent cleavage [1].
  • Analyses with serial deletions and point mutations show that MST has two functional nuclear export signals and, unexpectedly, another localization motif for nuclear import [1].
  • In this report, using anti-MST monoclonal antibodies, we clearly show that endogenous MST is localized in cytoplasm in a leptomycin B-dependent manner [1].
  • When cells are treated with leptomycin, monomeric MST is accumulated more rapidly in the nucleus than dimeric MST, indicating that dimerization contributes to the cytoplasmic retention of MST [1].
  • Furthermore, when stably expressed in HeLa cells, MST highly sensitizes the cells to death receptor-mediated apoptosis by accelerating caspase-3 activation [2].

Associations of Stk3 with chemical compounds


Biological context of Stk3

  • The cellular function and physiological activation mechanism of MST is unknown except for the proteolytic cleavage-induced activation in apoptosis [2].
  • However, kinase-deficient MST does not enter the nucleus, indicating that phosphorylation and activation is required for okadaic acid-induced nuclear translocation [1].

Other interactions of Stk3

  • MST, a physiological caspase substrate, highly sensitizes apoptosis both upstream and downstream of caspase activation [2].
  • During Fas-mediated apoptosis, cleaved MST translocates into the nucleus before nuclear fragmentation is initiated, suggesting it functions in the nucleus [2].


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