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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

METTL3  -  methyltransferase like 3

Homo sapiens

Synonyms: IME4, M6A, MT-A70, MTA70, Methyltransferase-like protein 3, ...
 
 
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High impact information on METTL3

  • MT-A70 is the S-adenosylmethionine-binding subunit of human mRNA:m(6)A methyl-transferase (MTase), an enzyme that sequence-specifically methylates adenines in pre-mRNAs [1].
  • MT-A70 cDNA probe hybridizes to a 2.0-kilobase (kb) polyadenylated RNA isolated from HeLa cells, whereas it hybridizes to two predominant RNA species (approximately 2.0 kb and 3.0 kb) using mRNA isolated from six different human tissues [2].
  • In general, the cell lines expressed a similar total amount of the MT-A70 mRNA while statistically significant differences existed between the quantity of the long and short forms among cell types [3].
  • Ribonuclease protection assays (RPA) were used to detect and quantitate the amount of messenger RNA (mRNA) coding for the S-adenosyl-L-methionine binding subunit (MT-A70) of the mRNA (N6-adenosine)-methyltransferase from different types of cultured cells [3].

References

  1. Structure prediction and phylogenetic analysis of a functionally diverse family of proteins homologous to the MT-A70 subunit of the human mRNA:m(6)A methyltransferase. Bujnicki, J.M., Feder, M., Radlinska, M., Blumenthal, R.M. J. Mol. Evol. (2002) [Pubmed]
  2. Purification and cDNA cloning of the AdoMet-binding subunit of the human mRNA (N6-adenosine)-methyltransferase. Bokar, J.A., Shambaugh, M.E., Polayes, D., Matera, A.G., Rottman, F.M. RNA (1997) [Pubmed]
  3. Expression of the mRNA (N6-adenosine)-methyltransferase S-adenosyl-L-methionine binding subunit mRNA in cultured cells. Leach, R.A., Tuck, M.T. Int. J. Biochem. Cell Biol. (2001) [Pubmed]
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