Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Gene Review:

otomp - otolith matrix protein

Danio rerio

Synonyms: OMP-1, Otolith matrix protein 1, SO:0000704, im:6904989, omp, ...

Celik, A. et al., Murayama, E. et al.

Celik, Fuss, Korsching, Murayama, Herbomel, Kawakami, Takeda, Nagasawa,

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High impact information on otomp

Otolith matrix proteins OMP-1 and Otolin-1 are necessary for normal otolith growth and their correct anchoring onto the sensory maculae [1].
During development, zOMP is expressed exclusively in the olfactory placode, presumably in olfactory receptor neurons, as shown by in situ hybridization [2].
In the adult nasal epithelium zOMP is found restricted to the sensory region. zOMP appears to be a single gene, without close family members [2].

Anatomical context of otomp

Thus the zOMP promoter constitutes a powerful tool which should be useful to selectively introduce a wide variety of genetic modifications into olfactory receptor neurons [2].

Analytical, diagnostic and therapeutic context of otomp

Whole-mount in situ hybridization then revealed that the expression of both zomp-1 and zotolin-1 mRNAs is restricted to the otic vesicles. zomp-1 mRNA was expressed from the 14-somite stage in the otic placode, but the zOMP-1 protein was detected only from 26-somite stage onwards [1].

References

Otolith matrix proteins OMP-1 and Otolin-1 are necessary for normal otolith growth and their correct anchoring onto the sensory maculae. Murayama, E., Herbomel, P., Kawakami, A., Takeda, H., Nagasawa, H. Mech. Dev. (2005) [Pubmed]
Selective targeting of zebrafish olfactory receptor neurons by the endogenous OMP promoter. Celik, A., Fuss, S.H., Korsching, S.I. Eur. J. Neurosci. (2002) [Pubmed]

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