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Rabgef1  -  RAB guanine nucleotide exchange factor...

Mus musculus

Synonyms: Rab5 GDP/GTP exchange factor, Rab5ef, Rabex-5, Rabex5, Ras negative regulator Rabex-5, ...
 
 
 
 
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High impact information on Rabgef1

  • We found that RabGEF1 (Rabex-5) binds to Ras and negatively regulates Ras activation and downstream effector pathways during FcepsilonRI-dependent mouse mast cell activation [1].

References

  1. RabGEF1, a negative regulator of Ras signalling, mast cell activation and skin inflammation. Tam, S.Y., Kalesnikoff, J., Nakae, S., Tsai, M., Galli, S.J. Novartis Found. Symp. (2005) [Pubmed]
 
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