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Gene Review

RABGEF1  -  RAB guanine nucleotide exchange factor...

Homo sapiens

Synonyms: RABEX5, RAP1, Rab5 GDP/GTP exchange factor, Rabaptin-5-associated exchange factor for Rab5, Rabex-5, ...
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High impact information on RABGEF1

  • Here, we report that Rabex-5, a guanine nucleotide exchange factor for Rab5, binds to Ub through two independent UBDs [1].
  • The other UBD, RUZ (Rabex-5 ubiquitin binding zinc finger) binds to a surface of Ub centered on Asp58(Ub) and distinct from the "canonical" Ile44(Ub)-based surface [1].
  • Rabex-5 forms a tight physical complex with Rabaptin-5, and this complex is essential for endocytic membrane fusion [2].
  • Two recent reports describe the crystal structure of the Rab5 guanine-nucleotide-exchange factor Rabex-5 and show that it contains two novel ubiquitin-binding domains [3].
  • These observations extend our understanding of the regulation of Rabex-5 by Rabaptin-5 [4].

Anatomical context of RABGEF1


Other interactions of RABGEF1

  • The yet unidentified cDNA of the human Rabex5 gene and the 3' untranslated region of the human caldesmon gene were cloned [6].


  1. Crystal structure of the ubiquitin binding domains of rabex-5 reveals two modes of interaction with ubiquitin. Penengo, L., Mapelli, M., Murachelli, A.G., Confalonieri, S., Magri, L., Musacchio, A., Di Fiore, P.P., Polo, S., Schneider, T.R. Cell (2006) [Pubmed]
  2. A novel Rab5 GDP/GTP exchange factor complexed to Rabaptin-5 links nucleotide exchange to effector recruitment and function. Horiuchi, H., Lippé, R., McBride, H.M., Rubino, M., Woodman, P., Stenmark, H., Rybin, V., Wilm, M., Ashman, K., Mann, M., Zerial, M. Cell (1997) [Pubmed]
  3. A new side to ubiquitin. Raiborg, C., Slagsvold, T., Stenmark, H. Trends Biochem. Sci. (2006) [Pubmed]
  4. The Rab5 guanine nucleotide exchange factor Rabex-5 binds ubiquitin (Ub) and functions as a Ub ligase through an atypical Ub-interacting motif and a zinc finger domain. Mattera, R., Tsai, Y.C., Weissman, A.M., Bonifacino, J.S. J. Biol. Chem. (2006) [Pubmed]
  5. Functional synergy between Rab5 effector Rabaptin-5 and exchange factor Rabex-5 when physically associated in a complex. Lippé, R., Miaczynska, M., Rybin, V., Runge, A., Zerial, M. Mol. Biol. Cell (2001) [Pubmed]
  6. Seven genes that are differentially transcribed in colorectal tumor cell lines. Nimmrich, I., Erdmann, S., Melchers, U., Finke, U., Hentsch, S., Moyer, M.P., Hoffmann, I., Müller, O. Cancer Lett. (2000) [Pubmed]
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