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Gene Review

PLSCR4  -  phospholipid scramblase 4

Homo sapiens

Synonyms: Ca(2+)-dependent phospholipid scramblase 4, Cell growth-inhibiting gene 43 protein, GIG43, PL scramblase 4, Phospholipid scramblase 4, ...
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Disease relevance of PLSCR4


High impact information on PLSCR4

  • The phospholipid scramblases (PLSCR1 to PLSCR4) are a structurally and functionally unique class of proteins, which are products of a tetrad of genes conserved from Caenorhabditis elegans to humans [2].
  • RESULTS: NT-hESC CD34(+) count was 7.6%, viability 100%, karyotyping normal, pluripotency markers: SSEA-1, SSEA-4, OCT-3/4, TRA-1/60:positive; 12% PBC was noted at 1 week after transplantation [3].

Other interactions of PLSCR4

  • CONCLUSION: The intrauterine expression of PLSCR3 and PLSCR4 provides a dynamic mechanism by which aminophospholipid translocation can be regulated, thereby modulating the activity of various membrane proteins that are involved in inflammation and coagulation-related events [1].


  1. Phospholipid scramblase isoform expression in pregnant rat uterus. Phillippe, M., Bradley, D.F., Ji, H., Oppenheimer, K.H., Chien, E.K. J. Soc. Gynecol. Investig. (2006) [Pubmed]
  2. Adiposity, dyslipidemia, and insulin resistance in mice with targeted deletion of phospholipid scramblase 3 (PLSCR3). Wiedmer, T., Zhao, J., Li, L., Zhou, Q., Hevener, A., Olefsky, J.M., Curtiss, L.K., Sims, P.J. Proc. Natl. Acad. Sci. U.S.A. (2004) [Pubmed]
  3. Embryonic stem cell derived and adult hematopoietic stem cell transplantation for tolerance induction in a renal allograft recipient:-a case report. Trivedi, H.L., Mishra, V.V., Vanikar, A.V., Modi, P.R., Shah, V.R., Shah, P.R., Firoz, A. Transplant. Proc. (2006) [Pubmed]
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