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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

CLK4  -  CDC-like kinase 4

Homo sapiens

Synonyms: Dual specificity protein kinase CLK4
 
 
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High impact information on CLK4

  • Molecular characterization of a cDNA encoding functional human CLK4 kinase and localization to chromosome 5q35 [correction of 4q35] [1].
  • When fused to glutathione S-transferase, the catalytically active human CLK4 is able to autophosphorylate and to phosphorylate myelin basic protein, but not histone H2B as a substrate [1].
  • Employing nucleotide sequence comparison of human expressed sequence tag sequences to the murine counterpart, we identified, cloned, and recombinantly expressed the human orthologue to the murine CLK4 cDNA [1].
  • A benzothiazole compound TG003, a kinase inhibitor that targets Clk1 and Clk4, suppressed dissociation of nuclear speckles, altered the splicing patterns, and rescued the embryonic defects induced by excessive Clk activity [2].
 

Analytical, diagnostic and therapeutic context of CLK4

References

  1. Molecular characterization of a cDNA encoding functional human CLK4 kinase and localization to chromosome 5q35 [correction of 4q35]. Schultz, J., Jones, T., Bork, P., Sheer, D., Blencke, S., Steyrer, S., Wellbrock, U., Bevec, D., Ullrich, A., Wallasch, C. Genomics (2001) [Pubmed]
  2. Alternative splicing: a new drug target of the post-genome era. Hagiwara, M. Biochim. Biophys. Acta (2005) [Pubmed]
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