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Gene Review

ARHGAP20  -  Rho GTPase activating protein 20

Homo sapiens

Synonyms: KIAA1391, Rho GTPase-activating protein 20, Rho-type GTPase-activating protein 20
 
 
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High impact information on ARHGAP20

  • Quantitative expression analysis in 22 B-CLLs revealed significant up-regulation of ARHGAP20 in CLL B cells, whereas BRWD3 was slightly down-regulated [1].
  • Thus, deregulation of ARHGAP20 by altered gene expression or by gene disruption (but not point mutation) might be a general molecular mechanism of B-CLL leukemogenesis [1].
  • Identification and characterization of human KIAA1391 and mouse Kiaa1391 genes encoding novel RhoGAP family proteins with RA domain and ANXL repeats [2].
  • We identified and characterized the KIAA1391 gene within the 11q23.1 commonly deleted region by using bioinformatics [2].

References

  1. Translocation t(X;11)(q13;q23) in B-cell chronic lymphocytic leukemia disrupts two novel genes. Kalla, C., Nentwich, H., Schlotter, M., Mertens, D., Wildenberger, K., Döhner, H., Stilgenbauer, S., Lichter, P. Genes Chromosomes Cancer (2005) [Pubmed]
  2. Identification and characterization of human KIAA1391 and mouse Kiaa1391 genes encoding novel RhoGAP family proteins with RA domain and ANXL repeats. Katoh, M., Katoh, M. Int. J. Oncol. (2003) [Pubmed]
 
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