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Gene Review:

BEGAIN - brain-enriched guanylate kinase-associated

Homo sapiens

Synonyms: Brain-enriched guanylate kinase-associated protein, KIAA1446

Yao, I. et al.

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High impact information on KIAA1446

NMDA receptor antagonists blocked localization of GFP-BEGAIN at synapses but did not affect recruitment to dendrites [1].
Approximately 75 and 90% of GFP-BEGAIN clusters were colocalized with synaptophysin and PSD-95/SAP90, respectively [1].
Green fluorescent protein (GFP)-tagged BEGAIN appeared first in nuclei and subsequently accumulated at dendrites [1].
BEGAIN was localized exclusively in nuclei when expressed in epithelial cells [1].

Analytical, diagnostic and therapeutic context of KIAA1446

In immunohistochemistry and immunocytochemistry, BEGAIN was detected in nuclei and at synapses in neurons [1].

References

Synaptic and nuclear localization of brain-enriched guanylate kinase-associated protein. Yao, I., Iida, J., Nishimura, W., Hata, Y. J. Neurosci. (2002) [Pubmed]

Contributions to this collaborative article are from individual authors of WikiGenes or mined by the WikiGenes Data Mining Engine from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.About WikiGenes Open Access Licence Privacy Policy Terms of Use apsburg

BEGAIN	Bos taurus
BEGAIN	Canis lupus familiaris
si:dkey-174m14.3	Danio rerio
BEGAIN	Gallus gallus
LOC717758	Macaca mulatta
Begain	Mus musculus
Begain	Rattus norvegicus
begain	Xenopus (Silurana) tropicalis

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