Gene Review:
GRIN1 - glutamate receptor, ionotropic, N-methyl D...
Homo sapiens
Synonyms:
GluN1, Glutamate receptor ionotropic, NMDA 1, MRD8, N-methyl-D-aspartate receptor subunit NR1, NMD-R1, ...
- Excitotoxic cell death and delayed rescue in human neurons derived from NT2 cells. Munir, M., Lu, L., Mcgonigle, P. J. Neurosci. (1995)
- Adult-onset hypothyroidism facilitates and enhances LTD: Reversal by chronic nicotine treatment. Alzoubi, K.H., Aleisa, A.M., Alkadhi, K.A. Neurobiol. Dis. (2007)
- Different capacities of various NMDA receptor antagonists to prevent ischemia-induced neurodegeneration in human cultured NT2 neurons. Garcia de Arriba, S., Wegner, F., Grüner, K., Verdaguer, E., Pallas, M., Camins, A., Wagner, A., Wohlfahrt, K., Allgaier, C. Neurochem. Int. (2006)
- The NR2B-selective NMDA receptor antagonist CP-101,606 exacerbates L-DOPA-induced dyskinesia and provides mild potentiation of anti-parkinsonian effects of L-DOPA in the MPTP-lesioned marmoset model of Parkinson's disease. Nash, J.E., Ravenscroft, P., McGuire, S., Crossman, A.R., Menniti, F.S., Brotchie, J.M. Exp. Neurol. (2004)
- Evidence that the N-methyl-D-aspartate subunit 1 receptor gene (GRIN1) confers susceptibility to bipolar disorder. Mundo, E., Tharmalingham, S., Neves-Pereira, M., Dalton, E.J., Macciardi, F., Parikh, S.V., Bolonna, A., Kerwin, R.W., Arranz, M.J., Makoff, A.J., Kennedy, J.L. Mol. Psychiatry (2003)
- Regulation of proteins affecting NMDA receptor-induced excitotoxicity in a Huntington's mouse model. Jarabek, B.R., Yasuda, R.P., Wolfe, B.B. Brain (2004)
- N-methyl-D-aspartate receptor antagonists enhance histamine neuron activity in rodent brain. Faucard, R., Armand, V., Héron, A., Cochois, V., Schwartz, J.C., Arrang, J.M. J. Neurochem. (2006)
- Dietary n-3 polyunsaturated fatty acid depletion activates caspases and decreases NMDA receptors in the brain of a transgenic mouse model of Alzheimer's disease. Calon, F., Lim, G.P., Morihara, T., Yang, F., Ubeda, O., Salem, N., Frautschy, S.A., Cole, G.M. Eur. J. Neurosci. (2005)
- Molecular interactions of the type 1 human immunodeficiency virus transregulatory protein Tat with N-methyl-d-aspartate receptor subunits. Chandra, T., Maier, W., König, H.G., Hirzel, K., Kögel, D., Schüler, T., Chandra, A., Demirhan, I., Laube, B. Neuroscience (2005)
- Mechanisms of spreading depression and hypoxic spreading depression-like depolarization. Somjen, G.G. Physiol. Rev. (2001)
- Cleavage at the caspase-6 site is required for neuronal dysfunction and degeneration due to mutant huntingtin. Graham, R.K., Deng, Y., Slow, E.J., Haigh, B., Bissada, N., Lu, G., Pearson, J., Shehadeh, J., Bertram, L., Murphy, Z., Warby, S.C., Doty, C.N., Roy, S., Wellington, C.L., Leavitt, B.R., Raymond, L.A., Nicholson, D.W., Hayden, M.R. Cell (2006)
- Dual regulation of NMDA receptor functions by direct protein-protein interactions with the dopamine D1 receptor. Lee, F.J., Xue, S., Pei, L., Vukusic, B., Chéry, N., Wang, Y., Wang, Y.T., Niznik, H.B., Yu, X.M., Liu, F. Cell (2002)
- EphB receptors interact with NMDA receptors and regulate excitatory synapse formation. Dalva, M.B., Takasu, M.A., Lin, M.Z., Shamah, S.M., Hu, L., Gale, N.W., Greenberg, M.E. Cell (2000)
- Ablation of cerebellar Golgi cells disrupts synaptic integration involving GABA inhibition and NMDA receptor activation in motor coordination. Watanabe, D., Inokawa, H., Hashimoto, K., Suzuki, N., Kano, M., Shigemoto, R., Hirano, T., Toyama, K., Kaneko, S., Yokoi, M., Moriyoshi, K., Suzuki, M., Kobayashi, K., Nagatsu, T., Kreitman, R.J., Pastan, I., Nakanishi, S. Cell (1998)
- Modulation of NMDA-mediated excitotoxicity by protein kinase C. Wagey, R., Hu, J., Pelech, S.L., Raymond, L.A., Krieger, C. J. Neurochem. (2001)
- Expression of functional NR1/NR2B-type NMDA receptors in neuronally differentiated SK-N-SH human cell line. Pizzi, M., Boroni, F., Bianchetti, A., Moraitis, C., Sarnico, I., Benarese, M., Goffi, F., Valerio, A., Spano, P. Eur. J. Neurosci. (2002)
- Pharmacological and immunological characterization of N-methyl-D-aspartate receptors in human NT2-N neurons. Munir, M., Lu, L., Wang, Y.H., Luo, J., Wolfe, B.B., McGonigle, P. J. Pharmacol. Exp. Ther. (1996)
- Agonist-induced down-regulation of NMDA receptors in cerebellar granule cells in culture. Resink, A., Villa, M., Boer, G.J., Möhler, H., Balázs, R. Eur. J. Neurosci. (1995)
- Felbamate block of recombinant N-methyl-D-aspartate receptors: selectivity for the NR2B subunit. Harty, T.P., Rogawski, M.A. Epilepsy Res. (2000)
- An association study of the N-methyl-D-aspartate receptor NR1 subunit gene (GRIN1) and NR2B subunit gene (GRIN2B) in schizophrenia with universal DNA microarray. Qin, S., Zhao, X., Pan, Y., Liu, J., Feng, G., Fu, J., Bao, J., Zhang, Z., He, L. Eur. J. Hum. Genet. (2005)
- N-methyl-D-aspartate receptor NR1 subunit gene (GRIN1) in schizophrenia: TDT and case-control analyses. Martucci, L., Wong, A.H., Trakalo, J., Cate-Carter, T., Wong, G.W., Macciardi, F.M., Kennedy, J.L. Am. J. Med. Genet. B Neuropsychiatr. Genet. (2003)
- Changing subunit composition of heteromeric NMDA receptors during development of rat cortex. Sheng, M., Cummings, J., Roldan, L.A., Jan, Y.N., Jan, L.Y. Nature (1994)
- Activation of NR1/NR2B NMDA receptors. Banke, T.G., Traynelis, S.F. Nat. Neurosci. (2003)
- Heteromeric NMDA receptors: molecular and functional distinction of subtypes. Monyer, H., Sprengel, R., Schoepfer, R., Herb, A., Higuchi, M., Lomeli, H., Burnashev, N., Sakmann, B., Seeburg, P.H. Science (1992)
- AMPA receptor-dependent clustering of synaptic NMDA receptors is mediated by Stargazin and NR2A/B in spinal neurons and hippocampal interneurons. Mi, R., Sia, G.M., Rosen, K., Tang, X., Moghekar, A., Black, J.L., McEnery, M., Huganir, R.L., O'Brien, R.J. Neuron (2004)
- Selected peptides targeted to the NMDA receptor channel protect neurons from excitotoxic death. Ferrer-Montiel, A.V., Merino, J.M., Blondelle, S.E., Perez-Payà, E., Houghten, R.A., Montal, M. Nat. Biotechnol. (1998)
- Selective alterations in gene expression for NMDA receptor subunits in prefrontal cortex of schizophrenics. Akbarian, S., Sucher, N.J., Bradley, D., Tafazzoli, A., Trinh, D., Hetrick, W.P., Potkin, S.G., Sandman, C.A., Bunney, W.E., Jones, E.G. J. Neurosci. (1996)
- Allosteric interaction between the amino terminal domain and the ligand binding domain of NR2A. Zheng, F., Erreger, K., Low, C.M., Banke, T., Lee, C.J., Conn, P.J., Traynelis, S.F. Nat. Neurosci. (2001)
- NMDA receptor channels: subunit-specific potentiation by reducing agents. Köhr, G., Eckardt, S., Lüddens, H., Monyer, H., Seeburg, P.H. Neuron (1994)
- Calcium-calmodulin-dependent protein kinase II phosphorylation modulates PSD-95 binding to NMDA receptors. Gardoni, F., Polli, F., Cattabeni, F., Di Luca, M. Eur. J. Neurosci. (2006)
- Pathophysiological implications of the structural organization of the excitatory synapse. Cattabeni, F., Gardoni, F., Di Luca, M. Eur. J. Pharmacol. (1999)
- The Rac1-GEF Tiam1 couples the NMDA receptor to the activity-dependent development of dendritic arbors and spines. Tolias, K.F., Bikoff, J.B., Burette, A., Paradis, S., Harrar, D., Tavazoie, S., Weinberg, R.J., Greenberg, M.E. Neuron (2005)
- The proteolytic activity of tissue-plasminogen activator enhances NMDA receptor-mediated signaling. Nicole, O., Docagne, F., Ali, C., Margaill, I., Carmeliet, P., MacKenzie, E.T., Vivien, D., Buisson, A. Nat. Med. (2001)
- Intersubunit cooperativity in the NMDA receptor. Regalado, M.P., Villarroel, A., Lerma, J. Neuron (2001)
- CaMKIIalpha enhances the desensitization of NR2B-containing NMDA receptors by an autophosphorylation-dependent mechanism. Sessoms-Sikes, S., Honse, Y., Lovinger, D.M., Colbran, R.J. Mol. Cell. Neurosci. (2005)
- PSD-95 and PKC converge in regulating NMDA receptor trafficking and gating. Lin, Y., Jover-Mengual, T., Wong, J., Bennett, M.V., Zukin, R.S. Proc. Natl. Acad. Sci. U.S.A. (2006)
- Identification of mouse NMDA receptor subunit NR2A C-terminal tyrosine sites phosphorylated by coexpression with v-Src. Yang, M., Leonard, J.P. J. Neurochem. (2001)
- Interleukin-2 inhibits NMDA receptor-mediated currents directly and may differentially affect subtypes. Shen, Y., Zhu, L.J., Liu, S.S., Zhou, S.Y., Luo, J.H. Biochem. Biophys. Res. Commun. (2006)
- The amino acid residue at sequence position 5 in the conantokin peptides partially governs subunit-selective antagonism of recombinant N-methyl-D-aspartate receptors. Klein, R.C., Prorok, M., Galdzicki, Z., Castellino, F.J. J. Biol. Chem. (2001)
- Hippocampal N-methyl-D-aspartate receptor subunit mRNA levels in temporal lobe epilepsy patients. Mathern, G.W., Pretorius, J.K., Mendoza, D., Leite, J.P., Chimelli, L., Born, D.E., Fried, I., Assirati, J.A., Ojemann, G.A., Adelson, P.D., Cahan, L.D., Kornblum, H.I. Ann. Neurol. (1999)
- Regional and ontogenic expression of the NMDA receptor subunit NR2D protein in rat brain using a subunit-specific antibody. Dunah, A.W., Yasuda, R.P., Wang, Y.H., Luo, J., Dávila-García, M., Gbadegesin, M., Vicini, S., Wolfe, B.B. J. Neurochem. (1996)
- Biochemical evidence for the co-association of three N-methyl-D-aspartate (NMDA) R2 subunits in recombinant NMDA receptors. Hawkins, L.M., Chazot, P.L., Stephenson, F.A. J. Biol. Chem. (1999)
- Differentiation of glycine antagonist sites of N-methyl-D-aspartate receptor subtypes. Preferential interaction of CGP 61594 with NR1/2B receptors. Honer, M., Benke, D., Laube, B., Kuhse, J., Heckendorn, R., Allgeier, H., Angst, C., Monyer, H., Seeburg, P.H., Betz, H., Mohler, H. J. Biol. Chem. (1998)
- The NMDA receptor complex is altered in an animal model of human cerebral heterotopia. Gardoni, F., Pagliardini, S., Setola, V., Bassanini, S., Cattabeni, F., Battaglia, G., Di Luca, M. J. Neuropathol. Exp. Neurol. (2003)
- Calcium-dependent inactivation of recombinant N-methyl-D-aspartate receptors is NR2 subunit specific. Krupp, J.J., Vissel, B., Heinemann, S.F., Westbrook, G.L. Mol. Pharmacol. (1996)