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Gene Review:

IGDCC4 - immunoglobulin superfamily, DCC subclass,...

Homo sapiens

Synonyms: DDM36, Immunoglobulin superfamily DCC subclass member 4, KIAA1628, LOC57722, NOPE, ...

Bezwoda, W.R. et al., Salbaum, J.M. et al.

Salbaum, Kappen,

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Disease relevance of NOPE

NOPE for relapsed aggressive diffuse non-Hodgkin's lymphoma [1].
Forty three patients with relapsed, diffuse aggressive lymphoma (Working Formulation Categories G to J) were treated with a combination chemotherapy regimen consisting of mitoxantrone 10 mg/m2 iv day 1, vincristine 1.4 mg/m2 iv day 1 and 14, prednisolone 50 mg/m2 p.o. days 1-5 and etoposide 100 mg/m2 p.o. days 1-5 of each cycle (NOPE) [1].

High impact information on NOPE

In the adult brain, Nope can be detected in the hippocampus [2].

References

NOPE for relapsed aggressive diffuse non-Hodgkin's lymphoma. Bezwoda, W.R., Bezwoda, M.A., Seymour, L., Dansey, R., Ariad, S. Leuk. Lymphoma (1993) [Pubmed]
Cloning and expression of nope, a new mouse gene of the immunoglobulin superfamily related to guidance receptors. Salbaum, J.M., Kappen, C. Genomics (2000) [Pubmed]

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