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Chemical Compound Review

Predate     (8R,9R,10S,11S,13S,14S,17R)- 11,17...

Synonyms: Cotolone, Dicortol, Erbacort, Erbasona, Predonine, ...
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Disease relevance of Predonine


Psychiatry related information on Predonine


High impact information on Predonine


Chemical compound and disease context of Predonine


Biological context of Predonine


Anatomical context of Predonine


Associations of Predonine with other chemical compounds


Gene context of Predonine

  • The expression was compared between different types of leukemia and was studied in relation with clinical risk indicators and in vitro cytotoxicity of the MDR-related drugs daunorubicin (DNR), vincristine (VCR), and etoposide (VP16) and the non-MDR-related drugs prednisolone (PRD) and L-asparaginase (ASP) [33].
  • Only prednisolone significantly reduced the expression of TNFalpha, IL-1beta, and IL-6 in the joints [34].
  • Incubation with 2 x 10(-8) M prednisolone down-regulated cell surface CD14 after 72 h, and 2 x 10(-7) M suppressed CD14 expression even after 24 h [35].
  • These results suggest that IL2 and IFN-gamma could enhance colonic epithelial cell injury mediated by the ADCC mechanism in ulcerative colitis and that ADCC enhanced by cytokines is restored by PSL treatment [36].
  • These results show that the overexpression of Delta F beta TrCP1 or beta TrCP1 in vivo induce tumors through beta-catenin activation [37].
  • Calcitonin (10(-10) mol/L) abrogated the stimulating effect of 10 ng/ml RANKL or 10(-9) mol/L prednisolone; similar results were obtained with OPG [38].

Analytical, diagnostic and therapeutic context of Predonine


  1. Effect of nebulized ipratropium on the hospitalization rates of children with asthma. Qureshi, F., Pestian, J., Davis, P., Zaritsky, A. N. Engl. J. Med. (1998) [Pubmed]
  2. A comparison of budesonide with prednisolone for active Crohn's disease. Rutgeerts, P., Löfberg, R., Malchow, H., Lamers, C., Olaison, G., Jewell, D., Danielsson, A., Goebell, H., Thomsen, O.O., Lorenz-Meyer, H. N. Engl. J. Med. (1994) [Pubmed]
  3. Trimethoprim-sulfamethoxazole (co-trimoxazole) for the prevention of relapses of Wegener's granulomatosis. Dutch Co-Trimoxazole Wegener Study Group. Stegeman, C.A., Tervaert, J.W., de Jong, P.E., Kallenberg, C.G. N. Engl. J. Med. (1996) [Pubmed]
  4. Efficacy of mycophenolate mofetil in patients with diffuse proliferative lupus nephritis. Hong Kong-Guangzhou Nephrology Study Group. Chan, T.M., Li, F.K., Tang, C.S., Wong, R.W., Fang, G.X., Ji, Y.L., Lau, C.S., Wong, A.K., Tong, M.K., Chan, K.W., Lai, K.N. N. Engl. J. Med. (2000) [Pubmed]
  5. Deleterious effect of prednisolone in HBsAg-positive chronic active hepatitis. Lam, K.C., Lai, C.L., Trepo, C., Wu, P.C. N. Engl. J. Med. (1981) [Pubmed]
  6. Prednisolone reduces recurrent wheezing after a first wheezing episode associated with rhinovirus infection or eczema. Lehtinen, P., Ruohola, A., Vanto, T., Vuorinen, T., Ruuskanen, O., Jartti, T. J. Allergy Clin. Immunol. (2007) [Pubmed]
  7. Controlled trial of prednisolone as adjuvant in treatment of tuberculous constrictive pericarditis in Transkei. Strang, J.I., Kakaza, H.H., Gibson, D.G., Girling, D.J., Nunn, A.J., Fox, W. Lancet (1987) [Pubmed]
  8. Energy expenditure and body composition in children with Crohn's disease: effect of enteral nutrition and treatment with prednisolone. Azcue, M., Rashid, M., Griffiths, A., Pencharz, P.B. Gut (1997) [Pubmed]
  9. Immunosuppressant pharmacodynamics on lymphocytes from healthy subjects and patients with chronic renal failure, nephrosis, and psoriasis: possible implications for individual therapeutic efficacy. Hirano, T., Oka, K., Takeuchi, H., Kozaki, K., Matsuno, N., Nagao, T., Kozaki, M., Ichikawa, M., Yoshida, M., Umezawa, Y., Hirata, M., Oh-i, T., Koga, M. Clin. Pharmacol. Ther. (1997) [Pubmed]
  10. Prednisolone (30-60 mg/day) for diseases other than AD decreases amyloid beta-peptides in CSF. Tokuda, T., Oide, T., Tamaoka, A., Ishii, K., Matsuno, S., Ikeda, S. Neurology (2002) [Pubmed]
  11. Effects of smoking cessation on lung function and airway inflammation in smokers with asthma. Chaudhuri, R., Livingston, E., McMahon, A.D., Lafferty, J., Fraser, I., Spears, M., McSharry, C.P., Thomson, N.C. Am. J. Respir. Crit. Care Med. (2006) [Pubmed]
  12. A preliminary study of long-term treatment with interferon gamma-1b and low-dose prednisolone in patients with idiopathic pulmonary fibrosis. Ziesche, R., Hofbauer, E., Wittmann, K., Petkov, V., Block, L.H. N. Engl. J. Med. (1999) [Pubmed]
  13. Azathioprine for long-term maintenance of remission in autoimmune hepatitis. Johnson, P.J., McFarlane, I.G., Williams, R. N. Engl. J. Med. (1995) [Pubmed]
  14. The effect of glucocorticoids on joint destruction in rheumatoid arthritis. The Arthritis and Rheumatism Council Low-Dose Glucocorticoid Study Group. Kirwan, J.R. N. Engl. J. Med. (1995) [Pubmed]
  15. A randomized trial of acyclovir for 7 days or 21 days with and without prednisolone for treatment of acute herpes zoster. Wood, M.J., Johnson, R.W., McKendrick, M.W., Taylor, J., Mandal, B.K., Crooks, J. N. Engl. J. Med. (1994) [Pubmed]
  16. Anti-inflammatory steroids without pituitary-adrenal suppression. Lee, H.J., Soliman, M.R. Science (1982) [Pubmed]
  17. Oral budesonide versus prednisolone in patients with active extensive and left-sided ulcerative colitis. Löfberg, R., Danielsson, A., Suhr, O., Nilsson, A., Schiöler, R., Nyberg, A., Hultcrantz, R., Kollberg, B., Gillberg, R., Willén, R., Persson, T., Salde, L. Gastroenterology (1996) [Pubmed]
  18. Mesalamine in Crohn's disease with steroid-induced remission: effect on steroid withdrawal and remission maintenance, Groupe d'Etudes Thérapeutiques des Affections Inflammatoires Digestives. Modigliani, R., Colombel, J.F., Dupas, J.L., Dapoigny, M., Costil, V., Veyrac, M., Duclos, B., Soulé, J.C., Gendre, J.P., Galmiche, J.P., Danne, O., Cadiot, G., Lamouliatte, H., Belaïche, J., Mary, J.Y. Gastroenterology (1996) [Pubmed]
  19. Treatment of membranous nephropathy with prednisolone and chlorambucil. Mavromatidis, C., Spaia, S., Christidou, F., Vayonas, G. Lancet (1989) [Pubmed]
  20. Role of platelet-activating factor in ulcerative colitis. Enhanced production during active disease and inhibition by sulfasalazine and prednisolone. Eliakim, R., Karmeli, F., Razin, E., Rachmilewitz, D. Gastroenterology (1988) [Pubmed]
  21. Comparison of three immunosuppressive regimens in cadaver renal transplantation: long-term cyclosporine, short-term cyclosporine followed by azathioprine and prednisolone, and azathioprine and prednisolone without cyclosporine. Hall, B.M., Tiller, D.J., Hardie, I., Mahony, J., Mathew, T., Thatcher, G., Miach, P., Thomson, N., Sheil, A.G. N. Engl. J. Med. (1988) [Pubmed]
  22. Kinetics and dynamics of prednisolone. Frey, F.J. Endocr. Rev. (1987) [Pubmed]
  23. Inhibition of osteoblastogenesis and promotion of apoptosis of osteoblasts and osteocytes by glucocorticoids. Potential mechanisms of their deleterious effects on bone. Weinstein, R.S., Jilka, R.L., Parfitt, A.M., Manolagas, S.C. J. Clin. Invest. (1998) [Pubmed]
  24. Prevention of osteocyte and osteoblast apoptosis by bisphosphonates and calcitonin. Plotkin, L.I., Weinstein, R.S., Parfitt, A.M., Roberson, P.K., Manolagas, S.C., Bellido, T. J. Clin. Invest. (1999) [Pubmed]
  25. Prednisone for chronic active liver disease: pharmacokinetics, including conversion to prednisolone. Schalm, S.W., Summerskill, W.H., Go, V.L. Gastroenterology (1977) [Pubmed]
  26. Effect of corticosteroids on suppressor-cell activity in "autoimmune" and viral chronic active hepatitis. Nouri-Aria, K.T., Hegarty, J.E., Alexander, G.J., Eddleston, A.L., Williams, R. N. Engl. J. Med. (1982) [Pubmed]
  27. Correction of human cyclic neutropenia with prednisolone. Wright, D.G., Fauci, A.S., Dale, D.C., Wolff, S.M. N. Engl. J. Med. (1978) [Pubmed]
  28. CFTR and differentiation markers expression in non-CF and delta F 508 homozygous CF nasal epithelium. Dupuit, F., Kälin, N., Brézillon, S., Hinnrasky, J., Tümmler, B., Puchelle, E. J. Clin. Invest. (1995) [Pubmed]
  29. Randomised controlled trial of steroid withdrawal in renal transplant recipients receiving triple immunosuppression. Ratcliffe, P.J., Dudley, C.R., Higgins, R.M., Firth, J.D., Smith, B., Morris, P.J. Lancet (1996) [Pubmed]
  30. Oral versus intravenous high-dose steroid treatment of renal allograft rejection. The big shot or not? Gray, D., Shepherd, H., Daar, A., Oliver, D.O., Morris, P.J. Lancet (1978) [Pubmed]
  31. De-novo autoimmune hepatitis after liver transplantation. Kerkar, N., Hadzić, N., Davies, E.T., Portmann, B., Donaldson, P.T., Rela, M., Heaton, N.D., Vergani, D., Mieli-Vergani, G. Lancet (1998) [Pubmed]
  32. Combined chemotherapy versus melphalan and prednisolone for treatment of myelomatosis. Gregory, W.M., Richards, M.A., Malpas, J.S. Lancet (1992) [Pubmed]
  33. Relationship between major vault protein/lung resistance protein, multidrug resistance-associated protein, P-glycoprotein expression, and drug resistance in childhood leukemia. den Boer, M.L., Pieters, R., Kazemier, K.M., Rottier, M.M., Zwaan, C.M., Kaspers, G.J., Janka-Schaub, G., Henze, G., Creutzig, U., Scheper, R.J., Veerman, A.J. Blood (1998) [Pubmed]
  34. Characterization of pristane-induced arthritis, a murine model of chronic disease: response to antirheumatic agents, expression of joint cytokines, and immunopathology. Patten, C., Bush, K., Rioja, I., Morgan, R., Wooley, P., Trill, J., Life, P. Arthritis Rheum. (2004) [Pubmed]
  35. Expression and release of the monocyte lipopolysaccharide receptor antigen CD14 are suppressed by glucocorticoids in vivo and in vitro. Nockher, W.A., Scherberich, J.E. J. Immunol. (1997) [Pubmed]
  36. Interleukin 2 and interferon-gamma augment anticolon antibody dependent cellular cytotoxicity in ulcerative colitis. Hibi, T., Ohara, M., Watanabe, M., Kanai, T., Takaishi, H., Hayashi, A., Hosoda, Y., Ogata, H., Iwao, Y., Aiso, S. Gut (1993) [Pubmed]
  37. Overexpression of human beta TrCP1 deleted of its F box induces tumorigenesis in transgenic mice. Belaïdouni, N., Peuchmaur, M., Perret, C., Florentin, A., Benarous, R., Besnard-Guérin, C. Oncogene (2005) [Pubmed]
  38. Calcitonin and prednisolone display antagonistic actions on bone and have synergistic effects in experimental arthritis. Mancini, L., Paul-Clark, M.J., Rosignoli, G., Hannon, R., Martin, J.E., Macintyre, I., Perretti, M. Am. J. Pathol. (2007) [Pubmed]
  39. Long-term clinical efficacy of grass-pollen immunotherapy. Durham, S.R., Walker, S.M., Varga, E.M., Jacobson, M.R., O'Brien, F., Noble, W., Till, S.J., Hamid, Q.A., Nouri-Aria, K.T. N. Engl. J. Med. (1999) [Pubmed]
  40. Immunohistological observations in rat kidney allografts after local steroid administration. Ruers, T.J., Buurman, W.A., van Boxtel, C.J., van der Linden, C.J., Kootstra, G. J. Exp. Med. (1987) [Pubmed]
  41. Nonenzymatic addition of glucocorticoids to lens proteins in steroid-induced cataracts. Manabe, S., Bucala, R., Cerami, A. J. Clin. Invest. (1984) [Pubmed]
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