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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

CCAR2  -  cell cycle and apoptosis regulator 2

Homo sapiens

Synonyms: Cell cycle and apoptosis regulator protein 2, Cell division cycle and apoptosis regulator protein 2, DBC-1, DBC.1, DBC1, ...
 
 
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Disease relevance of KIAA1967

  • Collectively, these findings establish a principal biological function for DBC-1 in the modulation of ERalpha expression and hormone-independent breast cancer cell survival [1].
 

High impact information on KIAA1967

  • We identified the generation of amino-terminally truncated versions of DBC-1 during tumor necrosis factor (TNF)-alpha-mediated apoptosis [2].
  • Endogenous DBC-1 localized to the nucleus in healthy cells, but localized to the cytoplasm during TNF-alpha-mediated apoptosis, consistent with the loss of the amino-terminus containing the nuclear localization signal [2].
  • Deleted in breast cancer-1 (DBC-1) was initially cloned from a homozygously deleted region in breast and other cancers on human chromosome 8p21, although no function is known for the protein product it encodes [2].

References

  1. Modulation of estrogen receptor alpha protein level and survival function by DBC-1. Trauernicht, A.M., Kim, S.J., Kim, N.H., Boyer, T.G. Mol. Endocrinol. (2007) [Pubmed]
  2. Caspase-dependent processing activates the proapoptotic activity of deleted in breast cancer-1 during tumor necrosis factor-alpha-mediated death signaling. Sundararajan, R., Chen, G., Mukherjee, C., White, E. Oncogene (2005) [Pubmed]
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