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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

SLC46A2  -  solute carrier family 46, member 2

Homo sapiens

Synonyms: Ly110, Solute carrier family 46 member 2, TSCOT, Thymic stromal cotransporter homolog
 
 
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High impact information on SLC46A2

  • We propose that the 9q32 region contains susceptibility locus for cervical cancer and that TSCOT is a candidate gene potentially involved in the genetic predisposition to this disease [1].
  • Analyses of TSCOT single nucleotide polymorphisms further strengthen the linkage to this region (MLS=2.40, P<0.001) [1].
  • Genomic clones spanning 17164 bases of the Tscot gene revealed four exons with nine of the TM domains encoded in the first exon [2].
  • Tscot was mapped to chromosome 4 and was also detected in other mammalian species by Southern blotting [2].
 

Analytical, diagnostic and therapeutic context of SLC46A2

  • Using competitive reverse transcription-polymerase chain reaction (RT-PCR), we show that low level Tscot expression is detectable in several other tissues [2].

References

  1. Identification of susceptibility loci for cervical carcinoma by genome scan of affected sib-pairs. Engelmark, M.T., Ivansson, E.L., Magnusson, J.J., Gustavsson, I.M., Beskow, A.H., Magnusson, P.K., Gyllensten, U.B. Hum. Mol. Genet. (2006) [Pubmed]
  2. Characterization of the mouse gene, human promoter and human cDNA of TSCOT reveals strong interspecies homology. Chen, C., Kim, M.G., Soo Lyu, M., Kozak, C.A., Schwartz, R.H., Flomerfelt, F.A. Biochim. Biophys. Acta (2000) [Pubmed]
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