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Gene Review

TP53INP2  -  tumor protein p53 inducible nuclear protein 2

Homo sapiens

Synonyms: C20orf110, DKFZp434B2411, DKFZp434O0827, DOR, Diabetes and obesity-regulated gene, ...
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Disease relevance of TP53INP2


High impact information on TP53INP2

  • We identified CDC91L1, the gene encoding CDC91L1 (also called phosphatidylinositol glycan class U (PIG-U), a transamidase complex unit in the glycosylphosphatidylinositol (GPI) anchoring pathway), as the only gene whose expression was affected by the translocation [2].
  • Assignment of the tumor protein p53 induced nuclear protein 2 (TP53INP2) gene to human chromosome band 20q11.2 by in situ hybridization [3].

Biological context of TP53INP2


Anatomical context of TP53INP2

  • CDC91L1 (PIG-U) was recently discovered as a new oncogene in human bladder cancer and showed mRNA overexpression in 36% of primary bladder tumor tissues compared to normal urothelium [1].


  1. CDC91L1 (PIG-U) mRNA expression in urothelial cell carcinomas. Schultz, I.J., Kiemeney, L.A., Witjes, J.A., Schalken, J.A., Willems, J.L., Swinkels, D.W., de Kok, J.B. Int. J. Cancer (2005) [Pubmed]
  2. CDC91L1 (PIG-U) is a newly discovered oncogene in human bladder cancer. Guo, Z., Linn, J.F., Wu, G., Anzick, S.L., Eisenberger, C.F., Halachmi, S., Cohen, Y., Fomenkov, A., Hoque, M.O., Okami, K., Steiner, G., Engles, J.M., Osada, M., Moon, C., Ratovitski, E., Trent, J.M., Meltzer, P.S., Westra, W.H., Kiemeney, L.A., Schoenberg, M.P., Sidransky, D., Trink, B. Nat. Med. (2004) [Pubmed]
  3. Assignment of the tumor protein p53 induced nuclear protein 2 (TP53INP2) gene to human chromosome band 20q11.2 by in situ hybridization. Nowak, J., Depetris, D., Iovanna, J.L., Mattei, M.G., Pébusque, M.J. Cytogenet. Genome Res. (2005) [Pubmed]
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